Punching Holes in Cellular Membranes: Biology and Evolution of Gasdermins

被引：99

作者：

De Schutter, Elke ^{[1
,2
,3
,4
]}

Roelandt, Ria ^{[1
,2
]}

Riquet, Franck B. ^{[1
,2
,5
]}

Van Camp, Guy ^{[3
,4
,6
]}

Wullaert, Andy ^{[1
,2
,7
]}

Vandenabeele, Peter ^{[1
,2
,8
]}

机构：

[1] Vlaams Inst Biotechnol VIB Ctr Inflammat Res, Ghent, Belgium

[2] Univ Ghent, Dept Biomed Mol Biol, Ghent, Belgium

[3] Univ Antwerp, Ctr Med Genet, Antwerp, Belgium

[4] Antwerp Univ Hosp, Antwerp, Belgium

[5] Univ Lille, Lille, France

[6] Univ Antwerp, Ctr Oncol Res, Antwerp, Belgium

[7] Univ Ghent, Dept Internal Med & Pediat, Ghent, Belgium

[8] Univ Ghent, Methusalem Program Cell Death Act Regulat Inflamm, Ghent, Belgium

来源：

TRENDS IN CELL BIOLOGY | 2021年 / 31卷 / 06期

关键词：

GASTROINTESTINAL-TRACT; GASTRIC-CANCER; PYROPTOSIS; GSDMD; GENE; CLEAVAGE; FAMILY; PORE; INFLAMMASOME; MUTATIONS;

D O I：

10.1016/j.tcb.2021.03.004

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The gasdermin (GSDM) family has evolved as six gene clusters (GSDMA-E and Pejvakin, PJVK), and GSDM proteins are characterized by a unique N-terminal domain (N-GSDM). With the exception of PJVK, the N-GSDM domain is capable of executing plasma membrane permeabilization. Depending on the cell death modality, several protease-and kinase-dependent mechanisms directly regulate the activity of GSDME and GSDMD, the two most widely expressed and best-studied GSDMs. We provide an overview of all GSDMs in terms of biological function, tissue expression, activation, regulation, and structure. In-depth phylogenetic analysis reveals that GSDM genes show many gene duplications and deletions, suggesting that strong evolutionary forces and a unique position of the PJVK gene are associated with the occurrence of complex inner-ear development in vertebrates.

引用

收藏

页码：500 / 513

页数：14

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