Planar Chiral [2.2]Paracyclophane-Based Bisoxazoline Ligands and Their Applications in Cu-Mediated N-H Insertion Reaction

被引：9
|
作者：
Knoll, Daniel M. [1 ]
Hu, Yuling [1 ]
Hassan, Zahid [1 ]
Nieger, Martin [2 ]
Braese, Stefan [1 ,3 ]
机构：
[1] Karlsruhe Inst Technol, IOC, Fritz Haber Weg 6, D-76131 Karlsruhe, Germany
[2] Univ Helsinki, Dept Chem, POB 55 AI Virtasen Aukio 1, FIN-00014 Helsinki, Finland
[3] Karlsruhe Inst Technol, ITG, Hermann von Helmholtz Pl 1, D-76344 Eggenstein Leopoldshafen, Germany
来源：
MOLECULES | 2019年 / 24卷 / 22期
关键词：
2; 2]paracyclophane ligands; N-H insertion; alpha-diazocarbonyls; planar chirality; copper catalysis; ASYMMETRIC CONJUGATE ADDITION; ENANTIOSELECTIVE INSERTION; BONDS; CATALYSTS; DESIGN; IMINES;
D O I：
10.3390/molecules24224122
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
New catalysts for important C-N bond formation are highly sought after. In this work, we demonstrate the synthesis and viability of a new class of planar chiral [2.2]paracyclophane-based bisoxazoline (BOX) ligands for the copper-catalyzed N-H insertion of alpha -diazocarbonyls into anilines. The reaction features a wide substrate scope and moderate to excellent yields, and delivers the valuable products at ambient conditions.
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页数：14
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