Antitumor functions and mechanisms of nitidine chloride in human cancers

被引：48

作者：

Cui, Yue ^{[1
]}

Wu, Linhui ^{[1
]}

Cao, Ruoxue ^{[1
]}

Xu, Hui ^{[2
]}

Xia, Jun ^{[3
]}

Wang, Z. Peter ^{[3
,4
]}

Ma, Jia ^{[3
]}

机构：

[1] Bengbu Med Coll, Res Ctr Clin Lab Sci, Sch Lab Med, Bengbu 233030, Anhui, Peoples R China

[2] Bengbu Med Coll, Sch Lab Med, Dept Lab Med, Bengbu 233030, Anhui, Peoples R China

[3] Bengbu Med Coll, Sch Lab Med, Dept Biochem & Mol Biol, Bengbu 233030, Anhui, Peoples R China

[4] Harvard Med Sch, Beth Israel Deaconess Med Ctr, Dept Pathol, Boston, MA 02115 USA

来源：

JOURNAL OF CANCER | 2020年 / 11卷 / 05期

关键词：

Nitidine chloride; Cancer; Therapy; Target; Antitumor; TO-MESENCHYMAL TRANSITION; CELL-PROLIFERATION; SIGNALING PATHWAY; OSTEOSARCOMA; EXPRESSION; APOPTOSIS; INVASION; MIGRATION; GROWTH; EPIDEMIOLOGY;

D O I：

10.7150/jca.37890

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Nitidine chloride (NC), a quaternary ammonium alkaloid, exhibits multiple biological activities, including antimalarial, antifungal, and antiangiogenesis. Recently, NC has been characterized to perform antitumor activity in a variety of malignancies. NC has been identified to suppress cell proliferation, stimulate apoptosis, and induce cell cycle arrest, retard migration, invasion and metastasis. Moreover, NC is reported to sensitize cancer cells to chemotherapeutic drugs. In this review article, we describe the functions of NC in human cancers and discuss the molecular insight into NC-involved antitumor feature. This review article will stimulate the deeper investigation for using NC as a potent agent for the management of cancer patients.

引用

页码：1250 / 1256

页数：7

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