(-)-Epigallocatechin-3-O-gallate (EGCG) reverses caffeine-induced anxiogenic-like effects

被引：30
作者：
Park, Kwang-Soon
Oh, Ju Hoon
Yoo, Hwan-Soo
Lee, Yong-Moon
Lee, Myung-Koo
Hong, Jin Tae
Oh, Ki-Wan [1 ]
机构：
[1] Chungbuk Natl Univ, Coll Pharm, Cheongju 361763, South Korea
来源：
NEUROSCIENCE LETTERS | 2010年 / 481卷 / 02期
关键词：
Epigallocatechin-3-O-gallate (EGCG); Caffeine; Anxiogenic; Electroencephalogram (EEG); Fast/slow waves (FW/SW) ratios; ALPHA-OSCILLATIONS; BRAIN OSCILLATIONS; ANXIETY; GALLATE; MICE;
D O I：
10.1016/j.neulet.2010.06.072
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
This study was designed to determine whether (-)-epigallocatethin-3-O-gallate (EGCG) could reverse caffeine-induced anxiogenic-like effects in animals. In mice, EGCG antagonized the caffeine-induced reduction in both the open arm entry number and time-spent in open arm on elevated plus-maze. In addition, EGCG also antagonized the caffeine-induced reduction in both the central zone distance and central zone time-spent on an open field apparatus, respectively. Electroencephalogram (EEG) was recorded from the rat anterior cerebral cortex. Caffeine increased the power density-ratios of fast (FW: 8.00-20.00 Hz) and slow (SW: 0.75-8.00 Hz) frequency spectrum bands in these EEG recordings. However, EGCG reduced the caffeine-induced increase of FW/SW ratios. Thus, EGCG reverses caffeine-induced anxiogenic-like effects. We also provide additional evidence that the EEG FW/SW (or SW/FW) ratios can be a useful tool for the prediction of anxiogenic and/or anxiolytic effects in an animal model. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码：131 / 134
页数：4
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