In vivo magnetic resonance spectroscopy in the evaluation of mitochondrial disorders

被引：5

作者：

Arias-Mendoza, F ^{[1
]}

机构：

[1] Columbia Univ, Dept Radiol, Hatch Ctr MR Res, Neurol Inst Basement, New York, NY 10032 USA

来源：

MITOCHONDRION | 2004年 / 4卷 / 5-6期

关键词：

31P MR spectroscopy; chemical shift imaging; in vivo metabolism; neuromuscular disease; mitochondrial dysfunction; mitochondrial disorders;

D O I：

10.1016/j.mito.2004.07.034

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Magnetic resonance spectroscopy (MRS) has been utilized to study several metabolic pathways in vivo and in live tissues in vitro non-invasively. Despite its inherited lack of sensitivity, its application has extended all the way to in situ human tissues and organs since proper technical advancements were devised. Examples of its application described here demonstrate the value of in vivo MRS as a technique that determines parameters of mitochondrial dysfunction directly and indirectly which could be of value for the diagnosis, prognosis, and follow-up of mitochondrial disorders. (C) 2004 Elsevier B.V. and Mitochondria Research Society. All rights reserved.

引用

页码：491 / 501

页数：11

共 93 条

[41] ALTERATIONS IN BRAIN PHOSPHORUS-METABOLISM IN BIPOLAR DISORDER DETECTED BY INVIVO P-31 AND LI-7 MAGNETIC-RESONANCE SPECTROSCOPY [J].

KATO, T ;

TAKAHASHI, S ;

SHIOIRI, T ;

INUBUSHI, T .

JOURNAL OF AFFECTIVE DISORDERS, 1993, 27 (01) :53-59

[42] Comparison of the solubilizing ability of cyclodextrins and surfactants for (+)-α-pinene [J].

Katougi, Y ;

Saito, Y ;

Hashizaki, K ;

Taguchi, H ;

Ogawa, N .

JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY, 2001, 22 (2-3) :185-190

[43] QUANTITATIVE-ANALYSIS BY P-31 MAGNETIC-RESONANCE SPECTROSCOPY OF ABNORMAL MITOCHONDRIAL OXIDATION IN SKELETAL-MUSCLE DURING RECOVERY FROM EXERCISE [J].

KEMP, GJ ;

TAYLOR, DJ ;

THOMPSON, CH ;

HANDS, LJ ;

RAJAGOPALAN, B ;

STYLES, P ;

RADDA, GK .

NMR IN BIOMEDICINE, 1993, 6 (05) :302-310

[44] CONTROL OF PHOSPHOCRATINE RESYNTHESIS DURING RECOVERY FROM EXERCISE IN HUMAN SKELETAL-MUSCLE [J].

KEMP, GJ ;

TAYLOR, DJ ;

RADDA, GK .

NMR IN BIOMEDICINE, 1993, 6 (01) :66-72

[45] THE PRODUCTION, BUFFERING AND EFFLUX OF PROTONS IN HUMAN SKELETAL-MUSCLE DURING EXERCISE AND RECOVERY [J].

KEMP, GJ ;

TAYLOR, DJ ;

STYLES, P ;

RADDA, GK .

NMR IN BIOMEDICINE, 1993, 6 (01) :73-83

[46] COMPARISONS OF ATP TURNOVER IN HUMAN MUSCLE DURING ISCHEMIC AND AEROBIC EXERCISE USING P-31 MAGNETIC-RESONANCE SPECTROSCOPY [J].

KEMP, GJ ;

THOMPSON, CH ;

BARNES, PRJ ;

RADDA, GK .

MAGNETIC RESONANCE IN MEDICINE, 1994, 31 (03) :248-258

[47]

KENNAWAY NG, 1988, J BIOENERG BIOMEMBR, V20, P324

[48] Proton MR spectroscopy in infants with cerebral energy deficiency due to hypoxia and metabolic disorders [J].

Kugel, H ;

Heindel, W ;

Roth, B ;

Ernst, S ;

Lackner, K .

ACTA RADIOLOGICA, 1998, 39 (06) :701-710

[49] HIV-related metabolic abnormalities in the brain: Depiction with proton MR spectroscopy with short echo times [J].

Laubenberger, J ;

Haussinger, D ;

Bayer, S ;

Thielemann, S ;

Schneider, B ;

Mundinger, A ;

Hennig, J ;

Langer, M .

RADIOLOGY, 1996, 199 (03) :805-810

[50] MAGNETIC-RESONANCE ZEUGMATOGRAPHY [J].

LAUTERBUR, PC .

PURE AND APPLIED CHEMISTRY, 1974, 40 (1-2) :149-157

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