Immune effects and mechanisms of action of CpG motifs

被引：137

作者：

Krieg, AM

机构：

[1] Dept Vet Affairs Med Ctr, Iowa City, IA 52246 USA

[2] Univ Iowa, Coll Med, Dept Internal Med, Iowa City, IA 52242 USA

[3] Coley Pharmaceut Grp, Wellesley, MA 02481 USA

来源：

VACCINE | 2000年 / 19卷 / 06期

关键词：

CpG motifs; DN4; innate immunity; immunotherapy; dendritic cell;

D O I：

10.1016/S0264-410X(00)00249-8

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Bacterial DNA differs from vertebrate DNA in having a much higher content of unmethylated CpG dinucleotides, in particular, base contexts that are termed. 'CpG motifs'. The vertebrate immune system appears to have evolved pattern recognition molecules that recognize 'CpG motifs' as foreign, and trigger protective immune responses which are strongly Th1-biased. These responses can be mimicked using synthetic oligodeoxyribonucleotides, which have demonstrated remarkable utility as vaccine adjuvants and as as immunotherapeutics for treatment of cancer and allergic diseases. Published by Elsevier Science Ltd.

引用

页码：618 / 622

页数：5

共 54 条

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