Solid phase insertion of diamines into peptide chains

Diamines derived from naturally occurring aminoacids were inserted into peptide chains by the reaction of the monophthaloyl diamines with amino acid 1-benzotriazolyl esters, bound through their amino functions onto trityl-type resins. The phthaloyl group was removed and peptide chains using N-Fmoc amino acids, were assembled on the liberated amino function. The peptidyl diamides obtained, were cleaved from the resins with 'Bu-side chain protection remaining intact, or fully deprotected. (C) 2003 Elsevier Science Ltd. All rights reserved.