Synthesis and application of a molecularly imprinted polymer for the voltammetric determination of famciclovir

被引：54
作者：
El Gohary, Nesrine Abdelrehim [1 ]
Madbouly, Adel [2 ]
El Nashar, Rasha Mohamed [1 ,2 ]
Mizaikoff, Boris [3 ]
机构：
[1] German Univ Cairo, Dept Pharmaceut Chem, Fac Pharm & Biotechnol, New Cairo City, Egypt
[2] Cairo Univ, Dept Chem, Fac Sci, Giza, Egypt
[3] Univ Ulm, Inst Analyt & Bioanalyt Chem, D-89081 Ulm, Germany
来源：
BIOSENSORS & BIOELECTRONICS | 2015年 / 65卷
关键词：
Molecular imprinted polymers; MIPs; Famciclovir; Computational studies; Carbon paste electrode and cyclic voltammetry; ELECTROCHEMICAL SENSOR; SENSITIVE DETERMINATION; PASTE ELECTRODE; URINE; PHARMACOKINETICS; ACETAMINOPHEN; SELECTIVITY; LAMIVUDINE; CARBIDOPA;
D O I：
10.1016/j.bios.2014.10.024
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
A molecularly imprinted polymer (MIP) was synthesized and applied as additive within a carbon paste electrode for the cyclic voltammetric determination of famciclovir (FCV). Complementary computational studies were performed to study the intermolecular interactions in the pre-polymerization mixture. Derived from the computational studies, four MIP ratios were synthesized and their performance was evaluated using equilibrium rebinding assays. The MIP with the highest binding capacity was selected. A linear response was obtained in the range of 2.5 x 10(-6)-1.0 x 10(-3) M with a limit of detection at 7.5 x 10(-7) M. Finally, the developed MIP-voltammetry system was successfully applied for the determination of FCV in pure solutions and pharmaceutical preparations. (C) 2014 Elsevier B.V. All rights reserved.
引用
收藏
页码：108 / 114
页数：7
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