Solubilities of phenazopyridine, propranolol, and methimazole in supercritical carbon dioxide

被引：66

作者：

Yamini, Y ^{[1
]}

Arab, J ^{[1
]}

Asghari-khiavi, M ^{[1
]}

机构：

[1] Tarbiat Modarres Univ, Sch Chem, Dept Chem, Tehran, Iran

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2003年 / 32卷 / 01期

关键词：

solubility; supercritical; phenazopyridine; propranolol; methimazole;

D O I：

10.1016/S0731-7085(03)00016-5

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

The equilibrium solubilities of three drugs (phenazopyridine, propranolol and methimazole) were determined at temperatures ranging from 308 to 348 K and pressures from 122 to 355 bar in supercritical CO2 by a simple and reliable static method. The crossover region was observed for phenazopyridine, propranolol and methimazole at 180 bar. The solubilities were correlated using a semi empirical model. Correlation of the results shows good self-consistency of the data obtained. (C) 2003 Elsevier Science B.V. All rights reserved.

引用

页码：181 / 187

页数：7

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