Blockade of the CD47-SIRPα axis: a promising approach for cancer immunotherapy

被引:27
作者
Uger, Robert [1 ]
Johnson, Lisa [2 ]
机构
[1] Trillium Therapeut Inc, 2488 Dunwin Dr, Mississaugua, ON L5L 1J9, Canada
[2] Trillium Therapeut Inc, Translat Res, Mississaugua, ON, Canada
关键词
CD47; immunotherapy; lymphoma; macrophage; phagocytosis; CD47; MACROPHAGES;
D O I
10.1080/14712598.2020.1685976
中图分类号
Q81 [生物工程学(生物技术)]; Q93 [微生物学];
学科分类号
071005 ; 0836 ; 090102 ; 100705 ;
摘要
引用
收藏
页码:5 / 8
页数:4
相关论文
共 19 条
[1]  
Advani R, 2019, HEMATOL ONCOL, V37, P89
[2]  
[Anonymous], 2019, J CLIN ONCOL S
[3]   Anti-CD47 Antibody Synergizes with Rituximab to Promote Phagocytosis and Eradicate Non-Hodgkin Lymphoma [J].
Chao, Mark P. ;
Alizadeh, Ash A. ;
Tang, Chad ;
Myklebust, June H. ;
Varghese, Bindu ;
Gill, Saar ;
Jan, Max ;
Cha, Adriel C. ;
Chan, Charles K. ;
Tan, Brent T. ;
Park, Christopher Y. ;
Zhao, Feifei ;
Kohrt, Holbrook E. ;
Malumbres, Raquel ;
Briones, Javier ;
Gascoyne, Randy D. ;
Lossos, Izidore S. ;
Levy, Ronald ;
Weissman, Irving L. ;
Majeti, Ravindra .
CELL, 2010, 142 (05) :699-713
[4]   A phase I study of ALX148, a CD47 blocker, in combination with established anticancer antibodies in patients with advanced malignancy. [J].
Chow, Laura Quan Man ;
Gainor, Justin F. ;
Lakhani, Nehal J. ;
Chung, Hyun Cheol ;
Lee, Keun-Wook ;
Lee, Jeeyun ;
LoRusso, Patricia ;
Bang, Yung-Jue ;
Hodi, F. Stephen ;
Fanning, Philip ;
Zhao, Yonggang ;
Jin, Feng ;
Wan, Hong ;
Pons, Jaume ;
Randolph, Sophia ;
Messersmith, Wells A. .
JOURNAL OF CLINICAL ONCOLOGY, 2019, 37 (15)
[5]  
GILES C, 1981, BRIT J HAEMATOL, V48, P31
[6]   ALX148 blocks CD47 and enhances innate and adaptive antitumor immunity with a favorable safety profile [J].
Kauder, Steven E. ;
Kuo, Tracy C. ;
Harrabi, Ons ;
Chen, Amy ;
Sangalang, Emma ;
Doyle, Laura ;
Rocha, Sony S. ;
Bollini, Sangeetha ;
Han, Bora ;
Sim, Janet ;
Pons, Jaume ;
Wan, Hong, I .
PLOS ONE, 2018, 13 (08)
[7]   Association of CD47 with natural killer cell-mediated cytotoxicity of head-and-neck squamous cell carcinoma lines [J].
Kim, Min Jung ;
Lee, June-Chul ;
Lee, Jae-Jung ;
Kim, Soyeon ;
Lee, Sang Goo ;
Park, Seok-Woo ;
Sung, Myung Whun ;
Heo, Dae Seog .
TUMOR BIOLOGY, 2008, 29 (01) :28-34
[8]   TTI-621 (SIRPαFc), a CD47-blocking cancer immunotherapeutic, triggers phagocytosis of lymphoma cells by multiple polarized macrophage subsets [J].
Lin, Gloria H. Y. ;
Chai, Vien ;
Lee, Vivian ;
Dodge, Karen ;
Truong, Tran ;
Wong, Mark ;
Johnson, Lisa D. ;
Linderoth, Emma ;
Pang, Xinli ;
Winston, Jeff ;
Petrova, Penka S. ;
Uger, Robert A. ;
Viller, Natasja N. .
PLOS ONE, 2017, 12 (10)
[9]   Inhibition of SIRP in dendritic cells potentiates potent antitumor immunity [J].
Liu, Qiong ;
Wen, Wen ;
Tang, Liang ;
Qin, Chen-Jie ;
Lin, Yan ;
Zhang, Hui-Lu ;
Wu, Han ;
Ashton, Charles ;
Wu, Hong-Ping ;
Ding, Jin ;
Dong, Wei ;
Yu, Le-Xing ;
Yang, Wen ;
Huang, Dan-Dan ;
Wu, Meng-Chao ;
Wang, Hong-Yang ;
Yan, He-Xin .
ONCOIMMUNOLOGY, 2016, 5 (09)
[10]   CD47 blockade triggers T cell-mediated destruction of immunogenic tumors [J].
Liu, Xiaojuan ;
Pu, Yang ;
Cron, Kyle ;
Deng, Liufu ;
Kline, Justin ;
Frazier, William A. ;
Xu, Hairong ;
Peng, Hua ;
Fu, Yang-Xin ;
Xu, Meng Michelle .
NATURE MEDICINE, 2015, 21 (10) :1209-+