HVAD Usage and Outcomes in the Current Pediatric Ventricular Assist Device Field: An Advanced Cardiac Therapies Improving Outcomes Network (ACTION) Analysis

被引:22
作者
Auerbach, Scott R. [1 ]
Simpson, Kathleen E. [1 ]
机构
[1] Univ Colorado Denver, Childrens Hosp Colorado, Anschutz Med Campus,13123 E 16th Ave,B100, Aurora, CO 80045 USA
关键词
ventricular assist device; HVAD; pediatrics; pediatric heart transplant; pediatric heart failure; UNITED-STATES DATA; INTERAGENCY REGISTRY; HEART-TRANSPLANTATION; CHILDREN; SUPPORT; MORTALITY; FAILURE; BRIDGE;
D O I
10.1097/MAT.0000000000001373
中图分类号
R318 [生物医学工程];
学科分类号
0831 ;
摘要
Advanced Cardiac Therapies Improving Outcomes Network (ACTION) is the first pediatric ventricular assist device (VAD) quality improvement network (46 centers). We aimed to describe outcomes with the HeartWare HVAD from ACTION centers. Patients with an HVAD implant in the ACTION registry (April 2018-April 2020) were analyzed. Baseline characteristics, adverse events, and survival were described. There were 50 patients implanted with a HVAD during the study period [36 cardiomyopathy, 8 congenital heart disease (CHD), and 6 other] and 21 (42%) had a prior sternotomy. Median age (range) was 12.9 years (3.4-19.1), body surface area was 1.3 m(2) (0.56-2.62), and weight was 41.8 kg (12.8-135.3). Most were INTERMACS profile 2 (n = 26, 52%). Mechanical ventilation and ECMO were used pre-HVAD in 13 (26%) and 6 (12%), respectively. Median time on VAD was 71 (5-602) days. Survival was 96% at 1 year; 3 deaths were recorded, all of whom had CHD (p = 0.001). Neither ECMO nor mechanical ventilation were associated with death (p > 0.29). Most frequent AEs were bleeding (n = 7, 14%) and infection (n = 7, 14%). Stroke was rare (n = 2, 4%). ACTION Network HVAD outcomes were excellent, with 96% survival at 1 year and only 4% occurrence of stroke. Major bleeding and infection were the most common adverse events.
引用
收藏
页码:675 / 680
页数:6
相关论文
共 24 条
[1]   Berlin Heart EXCOR Pediatric Ventricular Assist Device for Bridge to Heart Transplantation in US Children [J].
Almond, Christopher S. ;
Morales, David L. ;
Blackstone, Eugene H. ;
Turrentine, Mark W. ;
Imamura, Michiaki ;
Massicotte, M. Patricia ;
Jordan, Lori C. ;
Devaney, Eric J. ;
Ravishankar, Chitra ;
Kanter, Kirk R. ;
Holman, William ;
Kroslowitz, Robert ;
Tjossem, Christine ;
Thuita, Lucy ;
Cohen, Gordon A. ;
Buchholz, Holger ;
St Louis, James D. ;
Khanh Nguyen ;
Niebler, Robert A. ;
Walters, Henry L., III ;
Reemtsen, Brian ;
Wearden, Peter D. ;
Reinhartz, Olaf ;
Guleserian, Kristine J. ;
Mitchell, Max B. ;
Bleiweis, Mark S. ;
Canter, Charles E. ;
Humpl, Tilman .
CIRCULATION, 2013, 127 (16) :1702-+
[2]   Infectious complications of ventricular assist device use in children in the United States: Data from the Pediatric Interagency Registry for Mechanical Circulatory Support (Pedimacs) [J].
Auerbach, Scott R. ;
Richmond, Marc E. ;
Schumacher, Kurt R. ;
Lopez-Colon, Dalia ;
Mitchell, Max B. ;
Turrentine, Mark W. ;
Cantor, Ryan S. ;
Niebler, Robert A. ;
Eghtesady, Pirooz .
JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2018, 37 (01) :46-53
[3]   Outcomes of children bridged to heart transplantation with ventricular assist devices - A multi-institutional study [J].
Blume, ED ;
Naftel, DC ;
Bastardi, HJ ;
Duncan, BW ;
Kirklin, JK ;
Webber, SA .
CIRCULATION, 2006, 113 (19) :2313-2319
[4]   Outcomes of children implanted with ventricular assist devices in the United States: First analysis of the Pediatric Interagency Registry for Mechanical Circulatory Support (PediMACS) [J].
Blume, Elizabeth D. ;
Rosenthal, David N. ;
Rossano, Joseph W. ;
Baldwin, J. Timothy ;
Eghtesady, Pirooz ;
Morales, David L. S. ;
Cantor, Ryan S. ;
Conway, Jennifer ;
Lorts, Angela ;
Almond, Christopher S. ;
Naftel, David C. ;
Kirklin, James K. .
JOURNAL OF HEART AND LUNG TRANSPLANTATION, 2016, 35 (05) :578-584
[5]   Significant mortality, morbidity and resource utilization associated with advanced heart failure in congenital heart disease in children and young adults [J].
Burstein, Danielle S. ;
Shamszad, Pirouz ;
Dai, Dingwei ;
Almond, Christopher S. ;
Price, Jack F. ;
Lill, Kimberly Y. ;
O'Connor, Matthew ;
Shaddy, Robert E. ;
Mascio, Christopher E. ;
Rossano, Joseph W. .
AMERICAN HEART JOURNAL, 2019, 209 :9-19
[6]   Worldwide Experience of a Durable Centrifugal Flow Pump in Pediatric Patients [J].
Conway, Jennifer ;
Miera, Oliver ;
Adachi, Iki ;
Maeda, Katsuhide ;
Eghtesady, Pirooz ;
Henderson, Heather T. ;
Guleserian, Kristine ;
Fan, Chu-Po S. ;
Kirk, Richard .
SEMINARS IN THORACIC AND CARDIOVASCULAR SURGERY, 2018, 30 (03) :327-335
[7]   Ventricular Assist Device Support as a Bridge to Transplantation in Pediatric Patients [J].
Dipchand, Anne I. ;
Kirk, Richard ;
Naftel, David C. ;
Pruitt, Elizabeth ;
Blume, Elizabeth D. ;
Morrow, Robert ;
Rosenthal, David ;
Auerbach, Scott ;
Richmond, Marc E. ;
Kirklin, James K. .
JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY, 2018, 72 (04) :402-415
[8]   Prospective Trial of a Pediatric Ventricular Assist Device [J].
Fraser, Charles D., Jr. ;
Jaquiss, Robert D. B. ;
Rosenthal, David N. ;
Humpl, Tilman ;
Canter, Charles E. ;
Blackstone, Eugene H. ;
Naftel, David C. ;
Ichord, Rebecca N. ;
Bomgaars, Lisa ;
Tweddell, James S. ;
Massicotte, M. Patricia ;
Turrentine, Mark W. ;
Cohen, Gordon A. ;
Devaney, Eric J. ;
Pearce, F. Bennett ;
Carberry, Kathleen E. ;
Kroslowitz, Robert ;
Almond, Christopher S. .
NEW ENGLAND JOURNAL OF MEDICINE, 2012, 367 (06) :532-541
[9]   Outcomes of Children Following a First Hospitalization for Dilated Cardiomyopathy [J].
Hollander, Seth A. ;
Bernstein, Daniel ;
Yeh, Justin ;
Dao, Duy ;
Sun, Heather Y. ;
Rosenthal, David .
CIRCULATION-HEART FAILURE, 2012, 5 (04) :437-443
[10]   The Creation of a Pediatric Health Care Learning Network: The ACTION Quality Improvement Collaborative [J].
Lorts, Angela ;
Smyth, Lauren ;
Gajarski, Robert J. ;
VanderPluym, Christina J. ;
Mehegan, Mary ;
Villa, Chet R. ;
Murray, Jenna M. ;
Niebler, Robert A. ;
Almond, Christopher S. ;
Thrush, Philip ;
O'Connor, Matthew J. ;
Conway, Jennifer ;
Sutcliffe, David L. ;
Lantz, Jodi E. ;
Zafar, Farhan ;
Morales, David L. S. ;
Peng, David M. ;
Rosenthal, David N. .
ASAIO JOURNAL, 2020, 66 (04) :441-446