Amphiphilic trismethylpyridylporphyrin-fullerene (C70) dyad: an efficient photosensitizer under hypoxia conditions

被引：31

作者：

Guan, Mirong ^{[1
]}

Qin, Tingxiao ^{[2
]}

Ge, Jiechao ^{[3
]}

Zhen, Mingming ^{[1
]}

Xu, Wei ^{[1
]}

Chen, Daiqin ^{[1
]}

Li, Shumu ^{[1
]}

Wang, Chunru ^{[1
]}

Su, Hongmei ^{[2
]}

Shu, Chunying ^{[1
]}

机构：

[1] Chinese Acad Sci, Inst Chem, Key Lab Mol Nanostruct & Nanotechnol, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China

[2] Chinese Acad Sci, Inst Chem, State Key Lab Mol React Dynam, BNLMS, Beijing 100190, Peoples R China

[3] Chinese Acad Sci, TIPC, Key Lab Photochem Convers & Optoelect Mat, Beijing 100190, Peoples R China

来源：

JOURNAL OF MATERIALS CHEMISTRY B | 2015年 / 3卷 / 05期

基金：

中国国家自然科学基金;

关键词：

SINGLET-OXYGEN GENERATION; PHOTODYNAMIC THERAPY; PHOTORADIATION THERAPY; ENERGY-TRANSFER; CANCER; PORPHYRIN; HEMATOPORPHYRIN; NANOPARTICLES; NANOPLATFORM; DELIVERY;

D O I：

10.1039/c4tb01314j

中图分类号：

TB3 [工程材料学]; R318.08 [生物材料学];

学科分类号：

0805 ; 080501 ; 080502 ;

摘要：

Amphiphilic trismethylpyridylporphyrin-C-70 (PC70) dyad with improved photosensitization has been successfully prepared. The PC70 dyad forms a liposomal nanostructure through molecular self-assembling. An increased absorption coefficient in the visible region, good biocompatibility, and high photostability were observed on the self-assembling structure. Surprisingly, in comparison with previously reported photosensitizer porphyrins, PC70 exhibited an enhanced photodynamic therapy (PDT) effect under hypoxia conditions. Further investigations illustrated that PC70 went through an extremely long-life triplet state (211.3 mu s) under hypoxia, which enabled the exiguous oxygen to approach and interact with the activated (P-3-C-70)* more efficiently and produce more singlet oxygen. This would overcome the problem of existing photosensitizers of low PDT efficiency in cancerous tissues under hypoxia. The excellent properties of PC70 dyad make it a promising phototherapeutic agent, especially for the treatment of early-and late-stage cancers under shallow and hypoxia tissues.

引用

页码：776 / 783

页数：8

共 73 条

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