Synthesis, characterization and screening of biological activity of Zn(II), Fe(II) and Mn(II) complexes with trithiocyanuric acid

被引:19
作者
Kopel, Pavel
Dolezal, Karel
Machala, Libor
Langer, Vratislav
机构
[1] Palacky Univ, Dept Inorgan Chem, CZ-77147 Olomouc, Czech Republic
[2] Inst Expt Bot ASCR, Lab Growth Regulators, CZ-78371 Olomouc, Czech Republic
[3] Palacky Univ, CZ-78371 Olomouc, Czech Republic
[4] Palacky Univ, Dept Expt Phys, CZ-77146 Olomouc, Czech Republic
[5] Chalmers, Dept Biol & Chem Engn, SE-41296 Gothenburg, Sweden
关键词
complexes; trithiocyanuric acid; cytotoxicity; crystal structure; Mossbauer spectra;
D O I
10.1016/j.poly.2006.11.022
中图分类号
O61 [无机化学];
学科分类号
070301 ; 081704 ;
摘要
New Zn(II), Fe(II) and Mn(II) complexes with a combination of nitrogen-donor ligands and trithiocyanuric acid (ttcH(3)) were prepared and characterized by elemental analysis, IR and UV-Vis spectroscopies. The antitumor activity of the prepared complexes, together with already known Ni(II) species, were assayed in vitro against G-361 (human malignant melanoma), HOS (human osteogenic sarcoma), K-562 (human chronic myelogenous leukaemia) and MCF-7 (human breast adenocarcinoma) tumor cell lines. The IC50 values of the Fe(II) and Mn(II) compounds turned out to be lower than those of cisplatin and oxaliplatin. The antimicrobial activities were evaluated by MIC against bacteria (Escherichia coli, Pseudomonas aeruginosa, Staphylococcus aureus and Enterococcus faecalis). The molecular structure of [Zn(taa)(ttcH)] center dot H2O (taa = tris(2-aminoethyl)amine) was determined by X-ray diffraction. The central atom is pentacoordinated by four N atoms of taa and one N atom of the ttcH dianion. (C) 2006 Elsevier Ltd. All rights reserved.
引用
收藏
页码:1583 / 1589
页数:7
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