rTMS of the prefrontal cortex in the treatment of chronic migraine: a pilot study

被引：193
作者：
Brighina, F [1 ]
Piazza, A [1 ]
Vitello, G [1 ]
Aloisio, A [1 ]
Palermo, A [1 ]
Daniele, O [1 ]
Fierro, B [1 ]
机构：
[1] Univ Palermo, Neurophysiol Unit, Palermo, Italy
来源：
JOURNAL OF THE NEUROLOGICAL SCIENCES | 2004年 / 227卷 / 01期
关键词：
chronic migraine; rTMS; left dorsolateral prefrontal cortex; migraine prophylaxis; kindlig; cortico-lymbic sensitization;
D O I：
10.1016/j.jns.2004.08.008
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
A recent fMRI study showed that dorsolateral prefrontal cortex (DLPFC) exerts an inhibitory control on pain pathways in humans. We investigated whether high-frequency rTMS over left DLPFC could ameliorate chronic migraine. Treatment consisted of 12 rTMS sessions, delivered in alternate days over left DLPFC. Sham rTMS was used as placebo. Eleven patients were randomly assigned to the rTMS (n=6) or to the placebo (n-5) treatment. Measures of attack frequency, headache index, number of abortive medications (outcome measures) were recorded in the month before, during and in the month after treatment. Subjects treated by rTMS showed a significant reduction of the outcome measures during and in the month after the treatment as compared to the month before treatment. No significant differences in the outcome measures were observed in the placebo group. High-frequency rTMS over left DLPFC was able to ameliorate chronic migraine. This is in agreement with the suggested role of DLPFC in pain control. (C) 2004 Elsevier B.V. All rights reserved.
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收藏
页码：67 / 71
页数：5
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