Cyclic guanosine monophosphate role in human carcinoma pathogenesis

被引：2

作者：

Di Nicola, M

Santoleri, F

Soscia, S

Fioroni, M

Rubini, C

Piattelli, A

Spoto, G ^{[1
]}

机构：

[1] Univ G DAnnunzio, Dept Appl Sci Oral & Dent Dis, I-66013 Chieti, Italy

[2] Univ Ancona, Sch Dent, Inst Pathol Anat & Histopathol, Ancona, Italy

来源：

NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS | 2004年 / 23卷 / 8-9期

关键词：

cyclase; phosphodiesterases; cGMP; cAMP; cell carcinoma;

D O I：

10.1081/NCN-200027778

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

In order to examine the cyclic nucleotides (cGMP) role in carcinoma growth and invasivity. We analyzed two cell lines, LSHT29 and 17GT, and tissues in patients with carcinoma and malignant tissues with (N+) and without (N-) lymph node metastases. Higher cGMP levels in pathological samples suggest a strong correlation between intracellular cGMP concentration and carcinoma progression.

引用

页码：1555 / 1558

页数：4

共 3 条

[1]

SPOTO G, 1994, ADV EXP MED BIOL, V370, P815

[2] Cyclic guanosine monophosphate phosphodiesterase activity in human gingival carcinoma [J].

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Rubini, C ;

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Di Nicola, M ;

Forcella, S ;

Piattelli, A .

JOURNAL OF ORAL PATHOLOGY & MEDICINE, 2003, 32 (04) :189-194

[3] A REVERSE-PHASE HPLC METHOD FOR CAMP PHOSPHODIESTERASE ACTIVITY [J].

SPOTO, G ;

WHITEHEAD, E ;

FERRARO, A ;

DITERLIZZI, PM ;

TURANO, C ;

RIVA, F .

ANALYTICAL BIOCHEMISTRY, 1991, 196 (02) :207-210

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