The role of p63 in epidermal morphogenesis and neoplasia

被引：9

作者：

McDade, Simon S. ^{[1
]}

McCance, Dennis J. ^{[1
]}

机构：

[1] Queens Univ Belfast, Sch Med Dent & Biomed Sci, Ctr Canc Res & Cell Biol, Belfast BT9 7BL, Antrim, North Ireland

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2010年 / 38卷

基金：

英国医学研究理事会;

关键词：

cancer; epidermis; keratinocyte; p63; p53; LI-FRAUMENI-SYNDROME; P53; FAMILY; MOUSE MODELS; TARGET GENES; STEM-CELLS; DIFFERENTIATION; DELTA-NP63; EXPRESSION; ISOFORMS; MUTANT;

D O I：

10.1042/BST0380223

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The p53 family of transcription factors is made up of p53, p63 and p73, which share significant structural homology. in particular, transcriptional complexity and the expression of multiple protein isoforms are an emergent trait of all family members. p63 is the evolutionarily eldest member of the p53 family and the various isoforms have critical roles in the development of stratifying epithelia. Recent results have uncovered additional splice variants, adding to the complexity of the transcriptional architecture of p63. These observations and the emerging extensive interplay between p63 and p53 in development, proliferation and differentiation underline the importance of considering all isoforms and family members in studies of the function of p53 family members.

引用

页码：223 / 228

页数：6

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