Caveolin-1 exists and may function in cardiomyocytes

被引：18

作者：

Cho, Woo Jung ^{[1
]}

Chow, Ava K. ^{[2
]}

Schulz, Richard ^{[1
,2
]}

Daniel, Edwin E. ^{[1
]}

机构：

[1] Univ Alberta, Dept Pharmacol, Edmonton, AB T6G 2H7, Canada

[2] Univ Alberta, Dept Pediat, Edmonton, AB T6G 2H7, Canada

来源：

CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY | 2010年 / 88卷 / 01期

关键词：

MMP-2; localization of caveolin-1; immunohistochemistry; caveolin-2; endothelial cells; cardiomyocytes; MATRIX METALLOPROTEINASE-2; KINASE; HEART; MICE;

D O I：

10.1139/Y09-114

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Whether ventricular cardiac myocytes of mouse contain caveolin-1 is disputed. It has been claimed to he exclusively in nearby endothelial cell profiles. Recently, matrix metalloproteinase-2 (MMP-2) was reported to be present in mouse ventricular cardiac myocytes, colocalized with caveolin-1, and caveolin-1 knockout was found to cause the loss of MMP-2 from mouse ventricular cardiac myocytes and affect their functioning. To resolve this dispute, We labeled cardiac myocytes with caveolin-1 and endothelial cells with caveolin-2. Caveolin-2 is agreed to be present exclusively in endothelial cells. The results showed that mouse ventricular myocytes were labeled with caveolin-1 antibodies independently of any caveolin-2 labeling, and endothelial cells were labeled with both caveolin-1 and caveolin-2 antibodies. This confirms that caveolin-1 is present in mouse ventricular cardiac myocytes its well its endothelial cells. Previous evidence confirms that loss of caveolin-1 affects the function of mouse ventricular cardiac myocytes and Suggests that MMP-2 may be involved.

引用

页码：73 / 76

页数：4

共 7 条

[1] Matrix metalloproteinase-2, caveolins, focal adhesion kinase and c-Kit in cells of the mouse myocardium [J].