A Comparison of Yttrium-90 Microsphere Radioembolization to Hepatic Arterial Infusional Chemotherapy for Patients with Chemo-refractory Hepatic Colorectal Metastases

被引：7

作者：

Cercek, Andrea ^{[1
]}

Gendel, Vyacheslav ^{[2
]}

Jabbour, Salma ^{[3
,4
]}

Moore, Dirk ^{[5
]}

Chen, Chunxia ^{[5
]}

Nosher, John ^{[2
,3
]}

Capanu, Marinela ^{[6
]}

Chou, Joanne F. ^{[6
]}

Boucher, Taryn ^{[1
]}

Kemeny, Nancy ^{[1
]}

Carpizo, Darren R. ^{[3
,7
]}

机构：

[1] Mem Sloan Kettering Canc Ctr, Dept Med, 1275 York Ave, New York, NY 10021 USA

[2] Rutgers Robert Wood Johnson Univ, Sch Med, Dept Radiol, New Brunswick, NJ USA

[3] Rutgers Canc Inst New Jersey, 195 Little Albany St, New Brunswick, NJ 08903 USA

[4] Rutgers Robert Wood Johnson Univ, Sch Med, Dept Radiat Oncol, New Brunswick, NJ USA

[5] Rutgers Canc Inst New Jersey, Dept Biostat, New Brunswick, NJ 08903 USA

[6] Mem Sloan Kettering Canc Ctr, Dept Epidemiol & Biostat, New York, NY 10021 USA

[7] Rutgers Robert Wood Johnson Univ, Div Surg Oncol, Dept Surg, Sch Med, New Brunswick, NJ 08901 USA

来源：

CURRENT TREATMENT OPTIONS IN ONCOLOGY | 2017年 / 18卷 / 07期

关键词：

Metastatic colorectal cancer; Refractory; Hepatic arterial infusion; Yttrium-90 microsphere radioembolization; Survival; UNRESECTABLE LIVER METASTASES; 1ST-LINE TREATMENT; RANDOMIZED-TRIAL; PHASE-II; SYSTEMIC CHEMOTHERAPY; PLUS IRINOTECAN; OPEN-LABEL; CANCER; RESECTION; DEXAMETHASONE;

D O I：

10.1007/s11864-017-0481-1

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Patients with unresectable hepatic colorectal metastases who become chemo-refractory have limited treatment options. Systemic chemotherapies such as TAS102 and regorafenib have been used in the refractory setting, but with only modest improvement in overall survival compared to best supportive care. In patients with liver-only or liver-dominant disease, direct chemotherapy to the liver such as hepatic artery infusional (HAI) chemotherapy and radioembolization (yttrium-90 (Y90)) should be considered. Due to the difficulty of HAI therapy post Y90 for technical reasons, we recommend HAI therapy prior to Y90.

引用

页数：12

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