Selective amine recognition: Development of a chemosensor for dopamine and norepinephrine

被引：172
作者：
Secor, KE [1 ]
Glass, TE [1 ]
机构：
[1] Univ Missouri, Dept Chem, Columbia, MO 65211 USA
来源：
ORGANIC LETTERS | 2004年 / 6卷 / 21期
关键词：
D O I：
10.1021/ol048625f
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
A boronic acid-containing coumarin aldehyde was designed and synthesized. The sensor binds to catecholamines such as dopamine and norepinephrine by forming an iminium ion with the amine as well as a boronate ester with the catechol. An internal hydrogen bond produces a colorimetric response to these analytes with good selectivity for catecholamines over simple amines. The fluorescence of the sensor is quenched by the catechol.
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页码：3727 / 3730
页数：4
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