Deep Brain Stimulation for Essential Tremor: A Systematic Review

被引:240
作者
Flora, Eliana Della [1 ]
Perera, Caryn L. [1 ]
Cameron, Alun L. [1 ]
Maddern, Guy J. [1 ,2 ,3 ]
机构
[1] Royal Australasian Coll Surg, ASERNIP S, Stepney, SA 5069, Australia
[2] Queen Elizabeth Hosp, Dept Surg, Woodville, SA 5011, Australia
[3] Univ Adelaide, Discipline Surg, Adelaide, SA, Australia
关键词
deep brain stimulation; essential tremor; systematic review; QUALITY-OF-LIFE; THALAMIC-STIMULATION; SUPPRESSION; THALAMOTOMY; NUCLEUS; EFFICACY; THERAPY; IMPACT;
D O I
10.1002/mds.23195
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Deep brain stimulation (DBS) is a neurosurgical treatment, which has proven useful in treating Parkinson's disease. This systematic review assessed the safety and effectiveness of DBS for another movement disorder, essential tremor. All studies concerning the use of DBS in patients with essential tremor were identified through searching of electronic databases and hand searching of reference lists. Studies were categorized as before/after DBS or DBS stimulation on/off to allow the effect of the stimulation to be analyzed separately to that of the surgery itself. A total of 430 patients who had received DBS for essential tremor were identified. Most of the reported adverse events were mild and could be treated through changing the stimulation settings. Generally, in all studies, there was a significant improvement in outcomes alter DBS compared with baseline scores. In addition, DBS was significantly better in testing when the stimulation was turned on, compared with stimulation turned off or baseline. Based on Level IV evidence, DBS is possibly a safe and effective therapy for essential tremor. 2010 Movement Disorder Society
引用
收藏
页码:1550 / 1559
页数:10
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