Cyclic ketones and substituted α-keto acids as alternative substrates for novel Biginelli-like scaffold syntheses

被引：89

作者：

Abelman, MM

Smith, SC

James, DR

机构：

[1] Signature BioSci Inc, Richmond, CA 94804 USA

[2] Syngenta Ltd, Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England

来源：

TETRAHEDRON LETTERS | 2003年 / 44卷 / 24期

关键词：

Biginelli; alpha-keto acid; dihydropyrimidinone; pyrrolidinium tosylate;

D O I：

10.1016/S0040-4039(03)00985-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The reactions of benzocyclic ketones and alpha-ketoacids as carbonyl components in the Biginelli reaction were investigated. These unusual Biginelli substrates furnished novel drug-like dihydropyrimidinone scaffolds suitable for further elaboration. (C) 2003 Elsevier Science Ltd. All rights reserved.

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页码：4559 / 4562

页数：4

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