Efficient Copper-Catalyzed Coupling Reaction for the Synthesis of Benzo[4,5]imidazo[1,2-b]pyrazoles

被引：1

作者：

Cui, Tao ^{[1
]}

Li, Congxiang ^{[1
]}

Li, Ming ^{[1
]}

Wen, Lirong ^{[1
]}

机构：

[1] Qingdao Univ Sci & Technol, Coll Chem & Mol Engn, State Key Lab Base Ecochem Engn, Qingdao 266042, Peoples R China

来源：

CHINESE JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 37卷 / 06期

基金：

中国国家自然科学基金;

关键词：

copper catalysis; C-N coupling reaction; heterocyclic ketene aminals; benzo[4,5]imidazo[1,2-b]pyrazoles; HETEROCYCLIC KETENE AMINALS; SOLVENT-FREE; REGIOSELECTIVE SYNTHESIS; BETA-KETOTHIOAMIDES; TANDEM REACTIONS; CASCADE REACTION; N-ARYLATIONS; C-N; ARYL;

D O I：

10.6023/cjoc201612029

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A fast and efficient CuI-catalyzed intramolecular C-N coupling reaction of N-(2-bromoary1)-1H-pyrazol-5-amines to synthesize benzo[4,5]imidazo[1,2-b]pyrazoles has been developed from N-(2-bromoaryl)-thioacetanilides. A series of benzo[4,5]imidazo[1,2-b]pyrazoles were obtained in excellent yields with CuI/heterocyclic ketene aminals catalytic system in the presence of Cs2CO3 in dimethyl sulfoxide (DMSO) at 120 degrees C within 10 min. The reaction provides an fast and efficient protocol to access a series of benzo[4,5]imidazo[1,2-b]pyrazoles in good to high yields.

引用

页码：1487 / 1493

页数：7

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