Epoxide hydrolase in asymmetric synthesis

This article summarizes the development of the epoxide hydrolases in asymmetric synthesis. Epoxide hydrolases are prevalent in the nature, especially in the microbial sources. EHs appear high enantio - and regioselective in hydrolyzing epoxides to give the corresponding vicinal diols. Recently, some groups used the biochemical catalysis and chemical catalysis in a one - pot manner to hydrolyze the epoxides into single diols with satisfaction yields and high enantiomeric excess. This progress paved the way for using the EHs in the fine organic industry.