Enantioenriched Naphthoquinone Mannich Bases by Organocatalyzed Nucleophilic Additions to in situ Formed Imines

被引：10

作者：

Ayaz, Muhammad ^{[1
]}

Westermann, Bernhard ^{[1
,2
]}

机构：

[1] Leibniz Inst Plant Biochem, Dept Bioorgan Chem, D-06120 Halle, Germany

[2] Univ Halle Wittenberg, Inst Organ Chem, D-06120 Halle, Germany

来源：

SYNLETT | 2010年 / 10期

关键词：

organocatalysis; enantioselective Mannich reaction; 1,4-addition; alpha-amidosulfone; naphthoquinone; ENANTIOSELECTIVE MICHAEL ADDITION; DYNAMIC KINETIC RESOLUTION; CELL-GROWTH; KETONES;

D O I：

10.1055/s-0029-1219946

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Organocatalytic nucleophilic addition of 2-hydroxyl-naphthaquinone to imines is reported. This new route can be used to produce enantioenriched Mannich bases with excellent yields and moderate enantioselectivities.

引用

页码：1489 / 1492

页数：4

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