Successful treatment of citalopram-induced anorgasmia by cyproheptadine

This is the first report of the use of cyproheptadine to treat anorgasmia induced by citalopram, a highly selective serotonine reuptake inhibitor (SSRI). Total anorgasmia of a 47 year-old man who suffered from severe unipolar major depression was successfully treated without adverse effects. This case strengthens the impression that anorgasmia associated with SSRIs is related primarily to the serotonine reuptake inhibition and not to various receptor bindings of different compounds.