The Molecular Basis of IL-10 Function: from Receptor Structure to the Onset of Signaling

被引：106

作者：

Walter, Mark R. ^{[1
]}

机构：

[1] Univ Alabama Birmingham, Dept Microbiol, Birmingham, AL 35294 USA

来源：

INTERLEUKIN-10 IN HEALTH AND DISEASE | 2014年 / 380卷

关键词：

VIRUS PROTEIN BCRF1; CRYSTAL-STRUCTURE; INTERLEUKIN-10; RECEPTOR; HUMAN CYTOMEGALOVIRUS; DENDRITIC CELLS; CELLULAR INTERLEUKIN-10; CHRONIC ENTEROCOLITIS; INTERFERON RECEPTORS; SOLUBLE RECEPTOR; KINASE DOMAINS;

D O I：

10.1007/978-3-662-43492-5_9

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Assembly of the cell surface IL-10 receptor complex is the first step in initiating IL-10 signaling pathways that regulate intestinal inflammation, viral persistence and even tumor surveillance. The discovery of IL-10 homologs in the genomes of herpes viruses suggests IL-10 signaling pathways can be manipulated at the level of the receptor complex. This chapter will describe our current molecular understanding of IL-10 receptor assembly based on crystal structures and biochemical analyses of cellular and viral IL-10 receptor complexes.

引用

页码：191 / 212

页数：22

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