Isolation and structure elucidation of an interaction product of aminotadalafil found in an illegal health food product

被引：26

作者：

Haeberli, Adrian ^{[2
]}

Girard, Philippe ^{[2
]}

Low, Min-Yong ^{[1
]}

Ge, Xiaowei ^{[1
]}

机构：

[1] Hlth Sci Author, Appl Sci Grp, Pharmaceut Lab, Singapore 169078, Singapore

[2] OMCL, CH-3000 Bern 9, Switzerland

来源：

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2010年 / 53卷 / 01期

关键词：

Health food; PDE-5; inhibitor; Adulterant; Aminotadalafil; NMR; DIETARY-SUPPLEMENT; TADALAFIL;

D O I：

10.1016/j.jpba.2010.03.008

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

An interaction product of aminotadalafil was isolated from an illegal health food product. The structure of the interaction product was elucidated by means of IR, NMR, and mass spectroscopy. The hitherto unknown compound was characterized as condensation product of aminotadalafil and hydroxymethylfuraldehyde and is probably the result of a drug-excipient incompatibility. (C) 2010 Published by Elsevier B.V.

引用

页码：24 / 28

页数：5

共 9 条

[1]

Akkan AA, 2001, NAHRUNG, V45, P43, DOI 10.1002/1521-3803(20010101)45:1<43::AID-FOOD43>3.0.CO

[2]

2-3

[3] Isolation and Structural Elucidation of Cyclopentynafil and N-Octylnortadalafil Found in a Dietary Supplement [J].

Hasegawa, Takashi ;

Takahashi, Kazunaga ;

Saijo, Masaaki ;

Ishii, Toshiyasu ;

Nagata, Tomoko ;

Kurihara, Masaaki ;

Haishima, Yuji ;

Goda, Yukihiro ;

Kawahara, Nobuo .

CHEMICAL & PHARMACEUTICAL BULLETIN, 2009, 57 (02) :185-189

[4] Structural elucidation of a tadalafil analogue found in a dietary supplement [J].

Hasegawa, Takashi ;

Saijo, Masaaki ;

Ishii, Toshiyasu ;

Nagata, Tomoko ;

Haishima, Yuji ;

Kawahara, Nobuo ;

Goda, Yukihiro .

JOURNAL OF THE FOOD HYGIENIC SOCIETY OF JAPAN, 2008, 49 (04) :311-315

[5] Identification of aminotadalafil and its stereoisomers contained in health foods using chiral liquid chromatography-mass spectrometry [J].

Kurita, Hiroyuki ;

Mizuno, Kumiko ;

Kuromi, Koichi ;

Suzuki, Nobuyuki ;

Ueno, Chie ;

Kamimura, Mitsuko ;

Fujiwara, Atsuko ;

Owada, Kazuhiro ;

Ogo, Naohisa ;

Yamamoto, Masatoshi .

JOURNAL OF HEALTH SCIENCE, 2008, 54 (03) :310-314

[6] HPLC and GC-MS screening of Chinese proprietary medicine for undeclared therapeutic substances [J].

Liu, SY ;

Woo, SO ;

Koh, HL .

JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2001, 24 (5-6) :983-992

[7] Fresh from the pipeline - Tadalafil and vardenafil [J].

Neumeyer, K ;

Kirkpatrick, P .

NATURE REVIEWS DRUG DISCOVERY, 2004, 3 (04) :295-296

[8] Detection of sildenafil analogues in herbal products for erectile dysfunction [J].

Oh, Sharon Sze-Yin ;

Zou, Peng ;

Low, Min-Yong ;

Koh, Hwee-Ling .

JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES, 2006, 69 (21) :1951-1958

[9] Structural elucidation of a tadalafil analogue found as an adulterant of a herbal product [J].

Zou, P ;

Hou, PL ;

Low, MY ;

Koh, HL .

FOOD ADDITIVES AND CONTAMINANTS PART A-CHEMISTRY ANALYSIS CONTROL EXPOSURE & RISK ASSESSMENT, 2006, 23 (05) :446-451

← 1 →