Isolation and structure elucidation of an interaction product of aminotadalafil found in an illegal health food product

被引：26
作者：
Haeberli, Adrian [2 ]
Girard, Philippe [2 ]
Low, Min-Yong [1 ]
Ge, Xiaowei [1 ]
机构：
[1] Hlth Sci Author, Appl Sci Grp, Pharmaceut Lab, Singapore 169078, Singapore
[2] OMCL, CH-3000 Bern 9, Switzerland
来源：
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS | 2010年 / 53卷 / 01期
关键词：
Health food; PDE-5; inhibitor; Adulterant; Aminotadalafil; NMR; DIETARY-SUPPLEMENT; TADALAFIL;
D O I：
10.1016/j.jpba.2010.03.008
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
An interaction product of aminotadalafil was isolated from an illegal health food product. The structure of the interaction product was elucidated by means of IR, NMR, and mass spectroscopy. The hitherto unknown compound was characterized as condensation product of aminotadalafil and hydroxymethylfuraldehyde and is probably the result of a drug-excipient incompatibility. (C) 2010 Published by Elsevier B.V.
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页码：24 / 28
页数：5
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