Chk1 is required for G2/M checkpoint response induced by the catalytic topoisomerase II inhibitor ICRF-193

被引：24

作者：

Robinson, Helen M. R.

Bratlie-Thoresen, Sigrid

Brown, Robert

Gillespie, David A. F.

机构：

[1] Beatson Inst Canc Res, Glasgow G61 1BD, Lanark, Scotland

[2] Univ Glasgow, Beatson Labs, CRUK, Ctr Oncol & Appl Pharmacol, Glasgow, Lanark, Scotland

[3] Univ Glasgow, Inst Biomed & Life Sci, Glasgow G12 8QQ, Lanark, Scotland

来源：

CELL CYCLE | 2007年 / 6卷 / 10期

关键词：

cell cycle; checkpoints; DNA damage; ICRF-193; Chk1; TOPO II; decatenation;

D O I：

10.4161/cc.6.10.4225

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

引用

页码：1265 / 1267

页数：3

共 10 条

[1] Hypersensitivity of nonhomologous DNA end-joining mutants to VP-16 and ICRF-193 - Implications for the repair of topoisomerase II-mediated DNA damage [J].

Adachi, N ;

Suzuki, H ;

Iiizumi, S ;

Koyama, H .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (38) :35897-35902

[2]

Baldwin E. L., 2005, Current Medicinal Chemistry - Anti-Cancer Agents, V5, P363, DOI 10.2174/1568011054222364

[3] A TOPOISOMERASE II-DEPENDENT G2 CYCLE CHECKPOINT IN MAMMALIAN-CELLS [J].

DOWNES, CS ;

CLARKE, DJ ;

MULLINGER, M ;

GIMENEZABIAN, JF ;

CREIGHTON, AM ;

JOHNSON, RT .

NATURE, 1994, 372 (6505) :467-470

[4] COMING UNDONE - HOW TO UNTANGLE A CHROMOSOME [J].

HOLM, C .

CELL, 1994, 77 (07) :955-957

[5] Cytometric assessment of DNA damage in relation to cell cycle phase and apoptosis [J].

Huang, X ;

Halicka, HD ;

Traganos, F ;

Tanaka, T ;

Kurose, A ;

Darzynkiewicz, Z .

CELL PROLIFERATION, 2005, 38 (04) :223-243

[6] DNA Damage Induced by DNA Topoisomerase I- and Topoisomerase II-Inhibitors Detected by Histone H2AXphosphorylation in Relation to the Cell Cycle Phase and Apoptosis [J].

Huang, Xuan ;

Traganos, Frank ;

Darzynkiewicz, Zbigniew .

CELL CYCLE, 2003, 2 (06) :614-619

[7] Cell cycle-dependent DNA damage signaling induced by ICRF-193 involves ATM, ATR, CHK2, and BRCA1 [J].

Park, Iha ;

Avraham, Hava Karsenty .

EXPERIMENTAL CELL RESEARCH, 2006, 312 (11) :1996-2008

[8] DNA mismatch repair and Chk1-dependent centrosome amplification in response to DNA alkylation damage [J].

Robinson, Helen M. R. ;

Black, Elizabeth J. ;

Brown, Robert ;

Gillespie, David A. F. .

CELL CYCLE, 2007, 6 (08) :982-992

[9] ANTITUMOR BISDIOXOPIPERAZINES INHIBIT YEAST DNA TOPOISOMERASE-II BY TRAPPING THE ENZYME IN THE FORM OF A CLOSED PROTEIN CLAMP [J].

ROCA, J ;

ISHIDA, R ;

BERGER, JM ;

ANDOH, T ;

WANG, JC .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (05) :1781-1785

[10] Chk1-deficient tumour cells are viable but exhibit multiple checkpoint and survival defects [J].

Zachos, G ;

Rainey, MD ;

Gillespie, DAF .

EMBO JOURNAL, 2003, 22 (03) :713-723

← 1 →