Malignant melanoma in early Parkinson's disease: The DATATOP trial

被引：40

作者：

Constantinescu, Radu ^{[1
]}

Romer, Megan ^{[1
]}

Kieburtz, Karl ^{[1
]}

机构：

[1] Univ Rochester, Med Ctr, Dept Neurol, Rochester, NY 14620 USA

来源：

MOVEMENT DISORDERS | 2007年 / 22卷 / 05期

关键词：

malignant melanoma; Parkinson's disease; levodopa;

D O I：

10.1002/mds.21273

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The available epidemiological data on the incidence of malignant melanoma in Parkinson's disease are contradictory. The role of levodopa therapy in this context has been debated. We identified all known cases of malignant melanoma (N = 5) in the DATATOP clinical trial cohort and compared that to published expected values (N = 1.5) for a standard healthy population. The standardized event ratio was 3.3 (95% confidence interval, 1.1-7.8), indicating that incidence of malignant melanoma was higher than expected. We found no association between levodopa therapy and the incidence of melanoma. (c) 2007 Movement Disorder Society.

引用

页码：720 / 722

页数：3

共 14 条

[1]

Edwards SJ, 1998, Health Technology Assessment, V2, P1

[2] Risk of cancer after the diagnosis of Parkinson's disease: A historical cohort study [J].

Elbaz, A ;

Peterson, BJ ;

Bower, JH ;

Yang, P ;

Maraganore, DM ;

McDonnell, SK ;

Ahlskog, JE ;

Rocca, WA .

MOVEMENT DISORDERS, 2005, 20 (06) :719-725

[3] Malignant melanoma and levodopa in Parkinson's disease: causality or coincidence? [J].

Fiala, KH ;

Whetteckey, J ;

Manyam, BV .

PARKINSONISM & RELATED DISORDERS, 2003, 9 (06) :321-327

[4] THE USE OF L-DOPA AND CARBIDOPA IN METASTATIC MALIGNANT-MELANOMA [J].

GURNEY, H ;

COATES, A ;

KEFFORD, R .

JOURNAL OF INVESTIGATIVE DERMATOLOGY, 1991, 96 (01) :85-87

[5] PARKINSONISM - ONSET PROGRESSION AND MORTALITY [J].

HOEHN, MM ;

YAHR, MD .

NEUROLOGY, 1967, 17 (05) :427-&

[6] LOW CANCER RATES AMONG PATIENTS WITH PARKINSONS-DISEASE [J].

JANSSON, B ;

JANKOVIC, J .

ANNALS OF NEUROLOGY, 1985, 17 (05) :505-509

[7] OCCURRENCE OF DIFFERENT CANCERS IN PATIENTS WITH PARKINSONS-DISEASE [J].

MOLLER, H ;

MELLEMKJAER, L ;

MCLAUGHLIN, JK ;

OLSEN, JH .

BRITISH MEDICAL JOURNAL, 1995, 310 (6993) :1500-1501

[8] Atypical cancer pattern in patients with Parkinson's disease [J].

Olsen, JH ;

Friis, S ;

Frederiksen, K ;

McLaughlin, JK ;

Mellemkjaer, L ;

Moller, H .

BRITISH JOURNAL OF CANCER, 2005, 92 (01) :201-205

[9] DATATOP - A MULTICENTER CONTROLLED CLINICAL-TRIAL IN EARLY PARKINSONS-DISEASE [J].

SHOULSON, I .

ARCHIVES OF NEUROLOGY, 1989, 46 (10) :1052-1060

[10] Levodopa therapy and the risk of malignant melanoma [J].

Siple, JF ;

Schneider, DC ;

Wanlass, WA ;

Rosenblatt, BK .

ANNALS OF PHARMACOTHERAPY, 2000, 34 (03) :382-385

← 1 2 →