Protective efficacy of Andrographolide against Nickel induced Sister Chromatid Exchanges in Human Lymphocytes

被引：0
作者：
Veena, Vishwakarma [1 ]
Sunil, Kumar [1 ]
Bharti, Yadav [1 ]
Ranjan, Gupta [2 ]
Neeraj, Aggarwal K. [3 ]
Anita, Yadav [1 ]
机构：
[1] Kurukshetra Univ, Dept Biotechnol, Kurukshetra, Haryana, India
[2] Kurukshetra Univ, Dept Biochem, Kurukshetra, Haryana, India
[3] Kurukshetra Univ, Dept Microbiol, Kurukshetra, Haryana, India
来源：
RESEARCH JOURNAL OF BIOTECHNOLOGY | 2021年 / 16卷 / 04期
关键词：
Nickel; andrographolide; Sister chromatid exchange; Genotoxiciity; Antigenotoxicity;
D O I：
暂无
中图分类号：
Q81 [生物工程学（生物技术）]; Q93 [微生物学];
学科分类号：
071005 ; 0836 ; 090102 ; 100705 ;
摘要：
Andrographolide, the main constituent of Andrographis paniculata is widely used as herbal remedy due to its anti-inflammatory, antioxidant and anti-cancer activities. In this study, antigenotoxic potential of andrographolide (AG) has been assessed by analyzing the DNA damage in the form of sister chromatid exchange (SCE) in cultured peripheral blood lymphocytes (PBLs). Cells treated with nickel chloride (1 mM) in combination with different concentration andrographolide (4-20 mu g/ml) showed significant (p<0.05) reduction in the formation of sister chromatid exchanges. The data suggests that andrographolide has strong antigenotoxic potential to inhibit sister chromatid exchanges induced by nickel.
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页码：1 / 5
页数：5
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