Separation and identification of sulfonamide drugs via SFC/FT-IR mobile-phase elimination interface

被引：4

作者：

Ashraf-Khorassani, M

Combs, MT

Taylor, LT ^{[1
]}

Willis, J

Liu, XJ

Frey, CR

机构：

[1] Virginia Tech, Dept Chem, Blacksburg, VA 24060 USA

[2] Lab Connect Inc, Marlborough, MA 01652 USA

[3] Gilson Inc, Middleton, WI 53562 USA

来源：

APPLIED SPECTROSCOPY | 1997年 / 51卷 / 12期

关键词：

supercritical fluid chromatography; Fourier transform infrared spectrometry; sulfonamides;

D O I：

10.1366/0003702971939848

中图分类号：

TH7 [仪器、仪表];

学科分类号：

0804 ; 080401 ; 081102 ;

摘要：

Packed-column supercritical fluid chromatography with a mobile-phase gradient of carbon dioxide and methanol has been performed on a mixture of eight sulfonamides. The analytes were detected and identified with Fourier transform infrared spectrometry, A commercial mobile-phase elimination interface (LC-Transform((R))) was employed. A fixed-integral restrictor afforded the decompression zone between the column and germanium disk where the analytes were deposited, Excellent-quality infrared spectra were obtained for all eight separated analytes.

引用

页码：1791 / 1795

页数：5

共 22 条

[1] CHROMATOGRAPHIC BEHAVIOR OF POLAR COMPOUNDS WITH LIQUID VS SUPERCRITICAL FLUID MOBILE PHASES [J].