Bioactive Diphenyl Ethers and Isocoumarin Derivatives from a Gorgonian-Derived Fungus Phoma sp (TA07-1)

被引：32

作者：

Shi, Ting ^{[1
,2
]}

Qi, Jun ^{[1
,2
]}

Shao, Chang-Lun ^{[1
,2
]}

Zhao, Dong-Lin ^{[1
,2
]}

Hou, Xue-Mei ^{[1
,2
]}

Wang, Chang-Yun ^{[1
,2
,3
]}

机构：

[1] Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Minist Educ China, Qingdao 266003, Peoples R China

[2] Qingdao Natl Lab Marine Sci & Technol, Lab Marine Drugs & Bioprod, Qingdao 266071, Peoples R China

[3] Ocean Univ China, Inst Evolut & Marine Biodivers, Qingdao 266003, Peoples R China

来源：

MARINE DRUGS | 2017年 / 15卷 / 06期

基金：

中国国家自然科学基金;

关键词：

gorgonian-derived fungus; Phoma sp; diphenyl ether; isocoumarin; antibacterial activity; POLYKETIDES; METABOLITES;

D O I：

10.3390/md15060146

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Three new diphenyl ether derivativesphomaethers A-C (1-3) and five known compoundsincluding a diphenyl ether analog, 2,3-dihydroxy-4-methoxy-5,6-dimethyl diphenyl ether (4); and four isocoumarin derivatives, diaportinol (5), desmethyldiaportinol (6), citreoisocoumarinol (7), and citreoisocoumarin (8)were isolated from a gorgonian-derived fungus Phoma sp. (TA07-1). Their structures were elucidated by extensive spectroscopic investigation. The absolute configurations of 1 and 2 were determined by acid hydrolysis reactions. It was the first report to discover the diphenyl glycoside derivatives from coral-derived fungi. Compounds 1, 3, and 4 showed selective strong antibacterial activity against five pathogenic bacteria with the minimum inhibiting concentration (MIC) values and minimum bactericidal concentration (MBC) values between 0.156 and 10.0 M.

引用

页数：7

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