Acute lymphoblastic leukemia and Klinefelter syndrome in children: Two cases and review of the literature

被引：15

作者：

Machatschek, JN

Schrauder, A

Helm, F

Schrappe, M

Claviez, A

机构：

[1] Univ Kiel, Dept Pediat, D-24105 Kiel, Germany

[2] Univ Munster, Dept Pediat, D-4400 Munster, Germany

[3] Univ Hannover, Dept Pediat, Hannover, Germany

来源：

PEDIATRIC HEMATOLOGY AND ONCOLOGY | 2004年 / 21卷 / 07期

关键词：

acute lymphoblastic leukemia; children; Klinefelter syndrome;

D O I：

10.1080/08880010490501024

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The occurrence of mediastinal germ cell tumor and breast cancer have been repeatedly reported in men with Klinefelter syndrome (KS) but this association is debated controversially for patients with hematologic malignancies. The authors describe 2 tall adolescents in whom diagnostic workup for acute lymphoblastic leukemia (ALL) revealed 47, XXY and 47, XXY/48, XXXY karyotype, respectively. Among 4195 registered male patients in the ALL-BFM study group since 1983, no further patients with ALL and KS were identified. Given the lack of epidemiological data, this retrospective analysis illustrates the association of previously described cases of hematologic malignancies with KS. In contrast to other chromosomal aberrations, the incidence of ALL does not seem to be increased in pediatric patients with KS.

引用

页码：621 / 626

页数：6

共 25 条

[1] KLINEFELTER SYNDROME PATIENT WITH CHRONIC MYELOGENOUS LEUKEMIA [J].

ADHVARYU, SG ;

JANI, KH ;

BALAR, DB ;

SHAH, PM .

CANCER GENETICS AND CYTOGENETICS, 1990, 48 (01) :135-137

[2] NON-HODGKINS-LYMPHOMA AND KLINEFELTER SYNDROME [J].

ATTARDMONTALTO, SP ;

SCHULLER, I ;

LASTOWSKA, MA ;

GIBBONS, B ;

KINGSTON, JE ;

EDEN, OB .

PEDIATRIC HEMATOLOGY AND ONCOLOGY, 1994, 11 (02) :197-200

[3] FREQUENCY OF CONSTITUTIONAL CHROMOSOME ALTERATIONS IN PATIENTS WITH HEMATOLOGIC NEOPLASIAS [J].

BENITEZ, J ;

VALCARCEL, E ;

RAMOS, C ;

AYUSO, C ;

CASCOS, AS .

CANCER GENETICS AND CYTOGENETICS, 1987, 24 (02) :345-354

[4] PREZYGOTIC DETERMINANTS IN ACUTE LEUKEMIA [J].

BORGES, WH ;

NICKLAS, JW ;

HAMM, CW .

JOURNAL OF PEDIATRICS, 1967, 70 (02) :180-+

[5] KLINEFELTER SYNDROME, TUMOR, AND SEXUAL PRECOCITY [J].

CHAUSSAIN, JL ;

LEMERLE, J ;

ROGER, M ;

JOB, JC .

JOURNAL OF PEDIATRICS, 1980, 97 (04) :607-609

[6] Down's syndrome in childhood acute lymphoblastic leukemia:: clinical characteristics and treatment outcome in four consecutive BFM trials [J].

Dördelmann, M ;

Schrappe, M ;

Reiter, A ;

Zimmermann, M ;

Graf, N ;

Schott, G ;

Lampert, F ;

Harbott, J ;

Niemeyer, C ;

Ritter, J ;

Dörffel, W ;

Nessler, G ;

Kühl, J ;

Riehm, H .

LEUKEMIA, 1998, 12 (05) :645-651

[7] ACUTE MONOBLASTIC LEUKEMIA OF INFANCY IN KLINEFELTERS-SYNDROME [J].

FOOT, ABM ;

OAKHILL, A ;

KITCHEN, C .

CANCER GENETICS AND CYTOGENETICS, 1992, 61 (01) :99-100

[8]

GALE GB, 1984, AM J PEDIAT HEMATOL, V6, P338

[9] Treatment of adult ALL according to protocols of the German Multicenter Study Group for Adult ALL (GMALL) [J].

Gökbuget, N ;

Hoelzer, D ;

Arnold, R ;

Böhme, A ;

Bartram, CR ;

Freund, M ;

Ganser, A ;

Kneba, M ;

Langer, W ;

Lipp, T ;

Ludwig, WD ;

Maschmeyer, G ;

Rieder, H ;

Thiel, E ;

Weiss, A ;

Messerer, D .

HEMATOLOGY-ONCOLOGY CLINICS OF NORTH AMERICA, 2000, 14 (06) :1307-+

[10] ACUTE LYMPHOBLASTIC-LEUKEMIA ASSOCIATED WITH KLINEFELTER SYNDROME [J].

GURGEY, A ;

KARA, A ;

TUNCER, M ;

ALIKASIFOGLU, M ;

TUNCBILEK, E .

PEDIATRIC HEMATOLOGY AND ONCOLOGY, 1994, 11 (02) :227-228

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