The modulatory influence of some Echinacea-based remedies on antibody production and cellular immunity in mice

被引:9
作者
Balan, Barbara Joanna [1 ]
Sokolnicka, Irena [2 ]
Skopinska-Rozewska, Ewa [3 ]
Skopinski, Piotr [4 ]
机构
[1] Med Univ Warsaw, Dept Immunol Biochem & Nutr, Pawinskiego 3 A, PL-01106 Warsaw, Poland
[2] Childrens Mem Hlth Inst, Blood Bank, Transfus Immunol Lab, Warsaw, Poland
[3] Med Univ Warsaw, Ctr Biostruct Res, Pathol Dept, PL-01106 Warsaw, Poland
[4] Med Univ Warsaw, Ctr Biostruct Res, Dept Histol & Embryol, PL-01106 Warsaw, Poland
关键词
mice; Echinacea purpurea; cellular and humoral immunity; PURPUREA; EXTRACTS; ANGIOGENESIS; TEMPERATURE; LYMPHOCYTES; ALKYLAMIDE; ALKAMIDES; RHODIOLA;
D O I
10.5114/ceji.2016.58813
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Echinacea purpurea-containing remedies are herbal medicines used in respiratory tract infections and several inflammatory conditions as enhancers of non-specific and modulators of specific cellular immunity. They also exert anti-inflammatory, anti-viral, and anti-microbial activity. The aim of the present study was to compare the in vivo influence of orally administered three Echinacea purpurea-based remedies (IMMUNAL drops, ECHINACEA FORTE drops, IMMUNAL FORTE tablets) on some parameters of cellular and humoral immunity in mice. Results: Feeding mice for seven days with IMMUNAL drops resulted in enhanced anti-SRBC antibody production and modulatory effect on proliferative response to PHA of their splenic lymphocytes. No stimulatory effect was observed on splenocytes chemokinesis. Mice fed with ECHINACEA FORTE drops presented enhanced response to PHA of their splenocytes. However, contrary to the previous group, no enhancement of antibody production was observed. In this group, lymphocyte-induced immunological angiogenesis (LIA) and chemokinesis (spontaneous migration -SM) of spleen lymphocytes was diminished after feeding mice with both doses (LIA) or with a higher dose (SM) of remedy. Lymphocyte-induced immunological angiogenesis activity of splenocytes collected from animals fed with prophylactic and therapeutic IMMUNAL FORTE tablet doses did not differ from the controls.
引用
收藏
页码:12 / 18
页数:7
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