Adult lung function and long-term air pollution exposure. ESCAPE: a multicentre cohort study and meta-analysis

被引：285

作者：

Adam, Martin ^{[1
,2
]}

Schikowski, Tamara ^{[1
,2
,4
]}

Elie Carsin, Anne ^{[8
]}

Cai, Yutong ^{[9
]}

Jacquemin, Benedicte ^{[8
,14
,15
]}

Sanchez, Margaux ^{[14
,15
]}

Vierkoetter, Andrea ^{[4
]}

Marcon, Alessandro ^{[20
]}

Keidel, Dirk ^{[1
,2
]}

Sugiri, Dorothee ^{[4
]}

Al Kanani, Zaina ^{[9
]}

Nadif, Rachel ^{[14
,15
]}

Siroux, Valerie ^{[16
,17
]}

Hardy, Rebecca ^{[10
]}

Kuh, Diana ^{[10
]}

Rochat, Thierry ^{[3
]}

Bridevaux, Pierre-Olivier ^{[3
]}

Eeftens, Marloes ^{[1
,2
,24
]}

Tsai, Ming-Yi ^{[1
,2
]}

Villani, Simona ^{[21
]}

Phuleria, Harish Chandra ^{[1
,2
]}

Birk, Matthias ^{[5
]}

Cyrys, Josef ^{[5
,6
]}

Cirach, Marta ^{[8
]}

de Nazelle, Audrey ^{[11
]}

Nieuwenhuijsen, Mark J. ^{[8
]}

Forsberg, Beril ^{[26
]}

de Hoogh, Kees ^{[9
]}

Declerq, Christophe ^{[18
]}

Bono, Roberto ^{[22
]}

Piccioni, Pavilio ^{[23
]}

Quass, Ulrich ^{[7
]}

Heinrich, Joachim ^{[5
]}

Jarvis, Deborah ^{[9
,12
]}

Pin, Isabelle ^{[16
,17
,19
]}

Beelen, Rob ^{[24
]}

Hoek, Gerard ^{[24
]}

Brunekreef, Bert ^{[24
,25
]}

Schindler, Christian ^{[1
,2
]}

Sunyer, Jordi ^{[8
]}

Kraemer, Ursula ^{[4
]}

Kauffmann, Francine ^{[14
]}

Hansell, Anna L. ^{[9
,13
]}

Kuenzli, Nino ^{[1
,2
]}

Probst-Hensch, Nicole ^{[1
,2
]}

机构：

[1] Swiss Trop & Publ Hlth Inst, CH-4002 Basel, Switzerland

[2] Univ Basel, Basel, Switzerland

[3] Univ Hosp Geneva, Div Pulm Med, Geneva, Switzerland

[4] Leibniz Res Inst Environm Med IUF, Dusseldorf, Germany

[5] Munchen & German Res Ctr Environm Hlth, Helmholtz Zentrum, Inst Epidemiol 1, Neuherberg, Germany

[6] Univ Augsburg, Ctr Environm Sci, D-86159 Augsburg, Germany

[7] IUTA Inst Energie & Umwelttech eV, Air Qual & Sustainable Nanotechnol, Duisburg, Germany

[8] Ctr Res Environm Epidemiol CREAL, Barcelona, Spain

[9] Univ London Imperial Coll Sci Technol & Med, Sch Publ Hlth, Dept Epidemiol & Biostat, MRC PHE Ctr Environm & Hlth, London SW7 2AZ, England

[10] Univ London Imperial Coll Sci Technol & Med, MRC Univ Unit Lifelong Hlth & Ageing, London SW7 2AZ, England

[11] Univ London Imperial Coll Sci Technol & Med, Ctr Environm Policy, London SW7 2AZ, England

[12] Univ London Imperial Coll Sci Technol & Med, Dept Resp Epidemiol & Publ Hlth, Natl Heart & Lung Inst, London SW7 2AZ, England

[13] Imperial Coll Healthcare NHS Trust, Publ Hlth & Primary Care Directorate, London, England

[14] INSERM, Ctr Res Epidemiol & Populat Hlth CESP, Resp & Environm Epidemiol Team, U1018, Villejuif, France

[15] Univ Paris Sud, UMRS 1018, Villejuif, France

[16] INSERM, U823, Environm Epidemiol Appl Reprod & Resp Hlth Team, Grenoble, France

[17] Univ Grenoble 1, Grenoble, France

[18] French Inst Publ Hlth Surveillance, St Maurice, France

[19] CHU Grenoble, La Tronche, France

[20] Univ Verona, Unit Epidemiol & Med Stat, Dept Publ Hlth & Community Med, I-37100 Verona, Italy

[21] Univ Pavia, Unit Biostat & Clin Epidemiol, Dept Publ Hlth Expt & Forens Med, I-27100 Pavia, Italy

[22] Univ Turin, Dept Publ Hlth & Pediat, Turin, Italy

[23] SC Pneumol CPA ASL 4 Turin, Turin, Italy

[24] Univ Utrecht, Inst Risk Assessment Sci, Utrecht, Netherlands

[25] Univ Med Ctr Utrecht, Julius Ctr Hlth Sci & Primary Care, Utrecht, Netherlands

[26] Umea Univ, Dept Publ Hlth & Clin Med, Umea, Sweden

来源：

EUROPEAN RESPIRATORY JOURNAL | 2015年 / 45卷 / 01期

关键词：

USE REGRESSION-MODELS; BODY-MASS INDEX; PM2.5; ABSORBENCY; FUNCTION DECLINE; OZONE EXPOSURE; OBESITY; NO2; PROJECT; AREAS; INFLAMMATION;

D O I：

10.1183/09031936.00130014

中图分类号：

R56 [呼吸系及胸部疾病];

学科分类号：

摘要：

The chronic impact of ambient air pollutants on lung function in adults is not fully understood. The objective of this study was to investigate the association of long-term exposure to ambient air pollution with lung function in adult participants from five cohorts in the European Study of Cohorts for Air Pollution Effects (ESCAPE). Residential exposure to nitrogen oxides (NO2, NON) and particulate matter (PM) was modelled and traffic indicators were assessed in a standardised manner. The spirometric parameters forced expiratory volume in 1 s (FEV1) and forced vital capacity (FVC) from 7613 subjects were considered as outcomes. Cohort-specific results were combined using meta-analysis. We did not observe an association of air pollution with longitudinal change in lung function, but we observed that a 10 mu g.m(-3) increase in NO2 exposure was associated with lower levels of FEV1 (-14.0 mL, 95% CI -25.8 to -2.1) and FVC (-14.9 mL, 95% CI -28.7 to -1.1). An increase of 10 mu g.m(-3) in PM10, but not other PM metrics (PM2.5, coarse fraction of PM, PM absorbance), was associated with a lower level of FEV1 (-44.6 mL, 95% CI -85.4 to -3.8) and FVC (-59.0 mL, 95% CI -112.3 to -5.6). The associations were particularly strong in obese persons. This study adds to the evidence for an adverse association of ambient air pollution with lung function in adults at very low levels in Europe.

引用

页码：38 / 50

页数：13

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