The novel c-MYC inhibitor IDP-121 exhibits strong anti-myeloma effect.

被引：0

作者：

Krzeminski, Patryk ^{[1
]}

Gonzalez-Mendez, Lorena ^{[1
]}

San Segundo, Laura ^{[1
]}

Mogollon, Pedro ^{[1
]}

Diaz, Andrea ^{[1
]}

Hernandez-Garcia, Susana ^{[1
]}

Algarin, Macarena ^{[1
]}

Martin-Sanchez, Montserrat ^{[1
]}

Cochete, Luis ^{[1
]}

Paino, Teresa ^{[1
]}

Esteban, Santiago ^{[2
]}

Nevola, Laura ^{[2
]}

Gutierrez, Norma C. ^{[1
]}

Mateos, Ma-Victoria ^{[1
]}

Garayoa, Mercedes ^{[1
]}

Ocio, Enrique M. ^{[3
]}

机构：

[1] Hosp Univ Salamanca IBSAL, Ctr Invest Canc IBMC CSIC USAL, Salamanca, Spain

[2] IDP Discovery Pharma, Barcelona, Spain

[3] Univ Cantabria, Hosp Univ Marques de Valdecilla IDIVAL, Santander, Spain

来源：

CANCER RESEARCH | 2021年 / 81卷 / 13期

关键词：

D O I：

暂无

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

1291

引用

页数：2

共 17 条

[1] Combined Targeting of Distinct c-Myc and JunB Transcriptional Programs Inducing Synergistic Anti-Myeloma Activity
Lind, Judith
Vallet, Sonia
Kollmann, Karoline
Aksoy, Osman
Sunder-Plassmann, Vincent
Fan, Fengjuan
Zwickl-Traxler, Elisabeth
Stoiber, Dagmar
Bakiri, Latifa
Wagner, Erwin F.
Sattler, Martin
Percherstorfer, Martin
Podar, Klaus
BLOOD, 2021, 138
[2] Combined targeting of distinct c-Myc and JunB transcriptional programs induces synergistic anti-myeloma activity
Lind, Judith
Vallet, Sonia
Kollmann, Karoline
Aksoy, Osman
Sunder-Plassmann, Vincent
Zwickl-Traxler, Elisabeth
Fan, Fengjuan
Stoiber-Sakaguchi, Dagmar
Bakiri, Latifa
Wagner, Erwin
Sattler, Martin
Pecherstorfer, Martin
Podar, Klaus
CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2021, 21 : S19 - S20
[3] Identification of a novel c-Myc inhibitor with antitumor effects on multiple myeloma cells
Yao, Ruosi
Sun, Xiaoyang
Xie, Yu
Sun, Xiaoshen
Yao, Yao
Li, Hujun
Li, Zhenyu
Gao, Jian
Xu, Kailin
BIOSCIENCE REPORTS, 2018, 38 : 1 - 11
[4] Directly targeting c-Myc contributes to the anti-multiple myeloma effect of anlotinib
Yang Cao
Huizhuang Shan
Meng Liu
Jia Liu
Zilu Zhang
Xiaoguang Xu
Yue Liu
Hanzhang Xu
Hu Lei
Miao Yu
Xingming Zhang
Wanting Liu
Zhilei Bu
Zhixiao Fang
Yanjie Ji
Hua Yan
Weiying Gu
Yingli Wu
Cell Death & Disease, 12
[5] Directly targeting c-Myc contributes to the anti-multiple myeloma effect of anlotinib
Cao, Yang
Shan, Huizhuang
Liu, Meng
Liu, Jia
Zhang, Zilu
Xu, Xiaoguang
Liu, Yue
Xu, Hanzhang
Lei, Hu
Yu, Miao
Zhang, Xingming
Liu, Wanting
Bu, Zhilei
Fang, Zhixiao
Ji, Yanjie
Yan, Hua
Gu, Weiying
Wu, Yingli
CELL DEATH & DISEASE, 2021, 12 (04)
[6] Treatment with the Novel TOPK Inhibitor OTS514 Exhibits Potent Anti-Myeloma Activity in Pre-Clinical Models
Stefka, Andrew
Johnson, David
Rosebeck, Shaun
Park, Jae-Hyun
Nakamura, Yusuke
Jakubowiak, Andrzej J.
BLOOD, 2017, 130
[7] miRNA-29a as a tumor suppressor mediates PRIMA-1Met-induced anti-myeloma activity by targeting c-Myc
Saha, Manujendra N.
Abdi, Jahangir
Yang, Yijun
Chang, Hong
ONCOTARGET, 2016, 7 (06) : 7149 - 7160
[8] Identification of a Novel c-Myc Inhibitor 7594-0037 by Structure-Based Virtual Screening and Investigation of Its Anti-Cancer Effect on Multiple Myeloma
Yao, Ruosi
Xie, Yu
Sun, Xiaoyang
Zhang, Menghui
Zhou, Jian
Liu, Linlin
Gao, Jian
Xu, Kailin
DRUG DESIGN DEVELOPMENT AND THERAPY, 2020, 14 : 3983 - 3993
[9] Tasquinimod Targets Immunosuppressive Myeloid Cells, Increases Osteogenesis and Has Direct Anti-Myeloma Effects By Inhibiting c-Myc Expression in Vitro and In Vivo
Fan, Rong
Satilmis, Hatice
Vandewalle, Niels
De Bruyne, Elke
Menu, Eline
Chantry, Andrew D.
Evans, Holly
Torngren, Marie
Eriksson, Helena
Breckpot, Karine
Maes, Ken
Vanderkerken, Karin
De Veirman, Kim
BLOOD, 2021, 138
[10] Novel dual-targeting c-Myc inhibitor D347-2761 represses myeloma growth via blocking c-Myc/Max heterodimerization and disturbing its stability
Ruosi Yao
Menghui Zhang
Jian Zhou
Linlin Liu
Yan Zhang
Jian Gao
Kailin Xu
Cell Communication and Signaling, 20

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