Radical Difluororomethylation of Thiols with Difluoromethylphosphonium Triflate under Photoredox Catalysis

被引：34

作者：

Ran, Yang ^{[1
]}

Lin, Qing-Yu ^{[1
]}

Xu, Xiu-Hua ^{[1
]}

Qing, Feng-Ling ^{[1
,2
]}

机构：

[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, 345 Lingling Lu, Shanghai 200032, Peoples R China

[2] Donghua Univ, Coll Chem Chem Engn & Biotechnol, 2999 North Renmin Lu, Shanghai 201620, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2017年 / 82卷 / 14期

基金：

中国国家自然科学基金;

关键词：

OXIDATIVE TRIFLUOROMETHYLTHIOLATION; S-DIFLUOROMETHYLATION; BORONIC ACIDS; DIFLUOROCARBENE; REAGENT; ARYL; ETHERS; DIFLUOROMETHYLTHIOETHERS; DISULFIDES; THIOETHERS;

D O I：

10.1021/acs.joc.7b01041

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A convenient, visible light-induced radical difluoromethylation of aryl-, heteroaryl-, and alkylthiols with difluoromethyltriphenylphosphonium triflate was developed to afford various difluoromethyl thioethers in moderate to excellent yields. The key reaction features include the use of a readily available CF2H radical source, mild reaction conditions, and excellent chemoselective "thiol-difluoromethylation.

引用

页码：7373 / 7378

页数：6

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