INFLUENCE OF THE COMPLEX TREATMENT OF ARTERIAL HYPERTENSION ON THE INDICATORS OF THE SYSTEMICAL IMMUNOINFLAMMATORY ACTIVATION IN PATIENTS WITH ARTERIAL HYPERTENSION WITH OBESITY AND GOUT

The aim of the study was to evaluate the effect of losartan and meltedonium dihydrate on the parameters of systemic immune activation in patients with essential hypertension with obesity and gout. The study involved 80 patients with essential hypertension II stage 2 degrees combined with obesity and gout. Indicators of systemic immune activation under the influence of standard therapy in the dynamics did not significantly change. Losartan on the background of standard therapy significantly lowered the level of IL-6. After 6 months of treatment, its concentration in the blood decreased by 10.81% (p<0.05), and the level of CRP - by 17.31% (p<0.05). Meldonium dihydrate significantly reduced the CRP level after 1 month of treatment by 9.22% (p<0.01), and after 6 months - by 11.48% (p<0.001). It should be noted that the dynamics of systemic immun activation rates was most pronounced while combination losartan and meltedium dihydrate. This is evidenced by a decrease level of the CRP in the blood in 23.39% (p<0.001) after 1 month of treatment, and after 6 months - by 35.01% (p<0.001) and IL-6 content, respectively, by 40,15% (p<0.001) and 62.10% (p<0.001). Thus, it has been found that the combined use of losartan and meltedonium dihydrate against the background of standard therapy was much more effective in reducing the systemic immune activation compared with the separate administration of these drugs.