Carbohydrate Alimentary Overload Laminitis

被引:38
作者
Pollitt, Christopher C. [1 ,2 ]
Visser, Michelle B. [1 ]
机构
[1] Univ Queensland, Sch Vet Sci, Fac Nat Resources Agr & Vet Sci, Brisbane, Qld 4072, Australia
[2] Univ Penn, New Bolton Ctr, Sch Vet Med, Laminitis Inst, Kennett Sq, PA 19348 USA
关键词
Equine laminitis; Carbohydrate overload; Oligofructose; Basement membrane; EQUINE LAMINITIS; POLYMYXIN-B; DEVELOPMENTAL-STAGE; ENDOTOXIN; HINDGUT; HORSES; PERMEABILITY; ACTIVATION; INDUCTION;
D O I
10.1016/j.cveq.2010.01.006
中图分类号
S85 [动物医学(兽医学)];
学科分类号
0906 ;
摘要
In acute laminitis, the suspensory apparatus of the distal phalanx fails at the lamellar dermal/epidermal interface. A grading system for the histopathology of laminitis is based on the consistent pattern of histologic changes to the secondary epidermal lamellae, basal cells, and basement membrane that occur as carbohydrate-induced laminitis develops. The actual trigger factors of carbohydrate-induced laminitis remain unidentified.
引用
收藏
页码:65 / +
页数:15
相关论文
共 38 条
[1]   Plasma concentrations of endotoxin and platelet activation in the developmental stage of oligofructose-induced laminitis [J].
Bailey, S. R. ;
Adair, H. S. ;
Reinemeyer, C. R. ;
Morgan, S. J. ;
Brooks, A. C. ;
Longhofer, S. L. ;
Elliott, J. .
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 2009, 129 (3-4) :167-173
[2]  
Belknap J., 2007, Proceedings ACVIM Forum, Seattle, Washington, USA, 6-9 June, 2007, P148
[3]   Lamellar pro-inflammatory cytokine expression patterns in laminitis at the developmental stage and at the onset of lameness:: innate vs. adaptive immune response [J].
Belknap, J. K. ;
Giguere, S. ;
Pettigrew, A. ;
Cochran, A. M. ;
Van Eps, A. W. ;
Pollitt, C. C. .
EQUINE VETERINARY JOURNAL, 2007, 39 (01) :42-47
[4]   Leukocyte emigration in the early stages of laminitis [J].
Black, SJ ;
Lunn, DP ;
Yin, CL ;
Hwang, M ;
Lenz, SD ;
Belknap, JK .
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 2006, 109 (1-2) :161-166
[5]   Gene expression in the lamellar dermis-epidermis during the developmental phase of carbohydrate overload-induced laminitis in the horse [J].
Budak, Murat T. ;
Orsini, James A. ;
Pollitt, Christopher C. ;
Rubinstein, Neal A. .
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 2009, 131 (1-2) :86-96
[6]   Cloning and expression of ADAM-related metalloproteases in equine laminitis [J].
Coyne, Michael J. ;
Cousin, Helene ;
Loftus, John P. ;
Johnson, Philip J. ;
Belknap, James K. ;
Gradil, Carlos M. ;
Black, Samuel J. ;
Alfandari, Dominique .
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 2009, 129 (3-4) :231-241
[7]  
CROSER EL, 2006, 52 ANN CONV AM ASS E, P542
[8]  
DELAAT MA, 2009, EQUINE VET J, V41, DOI DOI 10.2746/042516409X042475779
[9]   Calprotectin in Myeloid and Epithelial Cells of Laminae from Horses with Black Walnut Extract-Induced Laminitis [J].
Faleiros, R. R. ;
Nuovo, G. J. ;
Belknap, J. K. .
JOURNAL OF VETERINARY INTERNAL MEDICINE, 2009, 23 (01) :174-181
[10]   Use of serial laminar tissue collection via biopsy in conscious healthy horses [J].
Hanly, Brenna K. ;
Stokes, Ashley M. ;
Bell, Amy M. ;
Johnson, Jill R. ;
Keowen, Michael L. ;
Paulsen, Daniel B. ;
Sod, Gary A. ;
Moore, Rustin M. .
AMERICAN JOURNAL OF VETERINARY RESEARCH, 2009, 70 (06) :697-702