Structural Designs and Mechanogating Mechanisms of the Mechanosensitive Piezo Channels

被引：142

作者：

Jiang, Yan ^{[1
]}

Yang, Xuzhong ^{[1
]}

Jiang, Jinghui ^{[1
]}

Xiao, Bailong ^{[1
]}

机构：

[1] Tsinghua Univ, Beijing Adv Innovat Ctr Struct Biol, Sch Pharmaceut Sci,IDG McGovern Inst Brain Res, State Key Lab Membrane Biol,Tsinghua Peking Ctr L, Beijing 100084, Peoples R China

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2021年 / 46卷 / 06期

基金：

中国国家自然科学基金; 国家重点研发计划;

关键词：

ACTIVATED ION-CHANNEL; HEREDITARY XEROCYTOSIS; DISTAL ARTHROGRYPOSIS; TOUCH SENSATION; BLOOD-PRESSURE; MERKEL CELLS; MUTATIONS; PROPRIOCEPTION; TRANSDUCTION; PHENOTYPE;

D O I：

10.1016/j.tibs.2021.01.008

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The evolutionarily conserved Piezo channel family, including Piezo1 and Piezo2 in mammals, serves as versatile mechanotransducers in various cell types and consequently governs fundamental pathophysiological processes ranging from vascular development to the sense of gentle touch and tactile pain. Piezo1 /2 possess a unique 38-transmembrane (TM) helix topology and form a homotrimeric propeller-sh aped structure comprising a central ionconducting pore and three peripheral mechanosensing blades. The unusually curved TM region of the three blades shapes a signature nano-bowl configuration with potential to generate large in-plane membrane area expansion, which might confer exquisite mechanosensitivity to Piezo channels. Here, we review the current understanding of Piezo channels with a particular focus on their unique structural designs and elegant mechanogating mechanisms.

引用

页码：472 / 488

页数：17

共 140 条

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