Copper-Mediated Aerobic Oxidative Trifluoromethylation of Terminal Alkynes with Me3SiCF3

被引：260
作者：
Chu, Lingling [1 ]
Qing, Feng-Ling [1 ,2 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Organ Chem, Key Lab Organofluorine Chem, Shanghai 200032, Peoples R China
[2] Donghua Univ, Coll Chem Chem Engn & Biotechnol, Shanghai 201620, Peoples R China
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2010年 / 132卷 / 21期
基金：
中国国家自然科学基金;
关键词：
NUCLEOPHILIC TRIFLUOROMETHYLATION; BOND FORMATION; REDUCTIVE ELIMINATION; FACILE SYNTHESES; ORGANIC HALIDES; FLUORINE; FUNCTIONALIZATION; STRATEGIES; ALDEHYDES; IMINES;
D O I：
10.1021/ja102175w
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
An efficient copper-mediated trifluoromethylation of terminal alkynes with nucleophilic trifluoromethylating reagent (Me3SiCF3) was developed. Both aromatic alkynes and aliphatic alkynes were effective, and a variety of functionalities such as amino, -OMe, -CO2Et, -Br, and -NO2 were tolerated under the reaction conditions. This reaction provides a general, straightforward, and practically useful method to prepare trifluoromethylated acetylenes.
引用
收藏
页码：7262 / +
页数：3
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