Schizotypal disorder and schizophrenia: A profile analysis of neuropsychological functioning in Japanese patients

被引:15
|
作者
Matsui, Mie [1 ]
Yuuki, Hiromi
Kato, Kanade
Takeuchi, Ai
Nishiyama, Shimako
Bilker, Warren B.
Kurachi, Masayoshi
机构
[1] Toyama Univ, Grad Sch Med, Dept Neuropsychiat, Sugitani, Toyama 9300194, Japan
[2] Toyama Univ, Grad Sch Med, Dept Neuropsychol, Sugitani, Toyama 9300194, Japan
[3] Tokyo Med & Dent Univ, Sch Med, Sect Liaison Psychiat & Pallat Med, Tokyo, Japan
[4] Japan Sci & Technol Corp, Core Res Evolut Sci & Technol, Tokyo, Japan
[5] Univ Penn, Sch Med, Dept Biostat & Epidemiol, Philadelphia, PA 19104 USA
关键词
verbal memory; schizotypy; verbal fluency; frontal function; temporolimbic function; psychosis;
D O I
10.1017/S135561770707083X
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
This study compares neuropsychological functioning in a Japanese schizophrenia spectrum disorder group and a group of healthy Japanese volunteers. Participants were 37 patients diagnosed with schizophrenia, 28 schizotypal patients, and 99 psychiatrically-normal volunteers. A wide range of cognitive measures were examined. All participants completed a Japanese version of a neuropsychological battery assessing executive function, working memory, processing speed, language, verbal memory, and spatial organization. Comparisons of neuropsychological function demonstrated similarities and differences between patients diagnosed with schizotypal disorder and those diagnosed with schizophrenia. Impairments in verbal memory, language, and processing speed were common to both patient groups and may represent a vulnerability to schizophrenia. Impairments in aspects of working memory, spatial organization and executive function were preferentially observed in schizophrenia and may be features of the overt manifestation of psychosis. Possible differences in the contributions of prefrontal and temporolimbic structures provide direction for further studies.
引用
收藏
页码:672 / 682
页数:11
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