Active sleep-related depolarization of feline trigemino-thalamic afferent terminals

被引：4

作者：

Cairns, BE ^{[1
]}

Soja, PJ ^{[1
]}

机构：

[1] Univ British Columbia, Fac Pharmaceut Sci, Div Pharmacol & Toxicol, Vancouver, BC V6T 1Z3, Canada

来源：

NEUROREPORT | 1998年 / 9卷 / 04期

关键词：

brain stem; presynaptic depolarization (PD); presynaptic inhibition; sensory; sleep; trigeminal; trigemino-thalamic;

D O I：

10.1097/00001756-199803090-00001

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

PRESYNAPTIC depolarization of trigemino-thalamic (TGT) terminals may contribute to modulation of ascending ore-facial somatosensory information during active (or rapid eye movement) sleep. The relative excitability of TGT terminals was inferred from changes in the current required to maintain an antidromic firing probability of 50% (EC50) during quiet wakefulness as compared to active sleep. Depolarization or hyperpolarization of TGT terminals was defined as a decrease or increase, respectively, in the EC50. Overall, the EC50 of 8 TGT terminals was reduced by a mean 8.8 +/- 3.6 mu A during active sleep relative to quiet wakefulness. This result suggests that depolarization of TGT terminals, which may act to suppress the transfer of sensory information from the trigeminal nucleus to the thalamus, occurs during active sleep.

引用

页码：565 / 570

页数：6

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