IL-20 in rheumatoid arthritis

被引：20

作者：

Hsu, Yu-Hsiang ^{[1
]}

Chang, Ming-Shi ^{[2
]}

机构：

[1] Natl Cheng Kung Univ, Inst Clin Med, Tainan, Taiwan

[2] Natl Cheng Kung Univ, Coll Med, Dept Biochem & Mol Biol, Tainan, Taiwan

来源：

DRUG DISCOVERY TODAY | 2017年 / 22卷 / 06期

关键词：

POTENTIAL ROLE; EXPRESSION; ANTIBODY; INTERLEUKIN-20; RECEPTORS; CYTOKINE; DISEASE; IL-19; MICE;

D O I：

10.1016/j.drudis.2015.08.002

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Rheumatoid arthritis, a systemic autoimmune disease, causes chronic joint inflammation and bone destruction. Interleukin (IL)-20' s association with this disease, and its expression and regulation has been extensively studied since 2006. Anti-IL-20 antibody has paved the way to clinical trials aimed at blocking the pathogenic actions of IL-20 in rheumatoid arthritis. This review focuses on current knowledge of IL-20' s involvement in the pathogenesis of rheumatoid arthritis.

引用

页码：960 / 964

页数：5

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