Cholesterol Levels Are Associated with 30-day Mortality from Ischemic Stroke in Dialysis Patients

被引：4

作者：

Wang, I. -Kuan ^{[1
,2
,3
]}

Liu, Chung-Hsiang ^{[4
]}

Yen, Tzung-Hai ^{[5
,6
]}

Jeng, Jiann-Shing ^{[7
]}

Hsu, Shih-Pin ^{[8
]}

Chen, Chih-Hung ^{[9
,10
]}

Lien, Li-Ming ^{[11
,12
]}

Lin, Ruey-Tay ^{[13
]}

Chen, An-Chih ^{[14
]}

Lin, Huey-Juan ^{[15
]}

Chi, Hsin-Yi ^{[16
]}

Lai, Ta-Chang ^{[17
]}

Sun, Yu ^{[18
]}

Lee, Siu-Pak ^{[19
]}

Sung, Sheng-Feng ^{[20
]}

Chen, Po-Lin ^{[21
]}

Lee, Jiunn-Tay ^{[22
]}

Chiang, Tsuey-Ru ^{[23
]}

Lin, Shinn-Kuang ^{[24
]}

Muo, Chih-Hsin ^{[25
]}

Ma, Henry ^{[26
]}

Wen, Chi-Pang ^{[27
]}

Sung, Fung-Chang ^{[1
,25
]}

Hsu, Chung Y. ^{[1
,4
]}

机构：

[1] China Med Univ, Inst Clin Med Sci, 91 Hsueh Shih Rd, Taichung 404, Taiwan

[2] China Med Univ, Dept Internal Med, Coll Med, Taichung, Taiwan

[3] China Med Univ Hosp, Div Kidney Dis, Taichung, Taiwan

[4] China Med Univ Hosp, Dept Neurol, Taichung, Taiwan

[5] Chang Gung Mem Hosp, Div Nephrol, Taipei, Taiwan

[6] Chang Gung Univ, Coll Med, Taoyuan, Taiwan

[7] Natl Taiwan Univ Hosp, Neurol, Taipei, Taiwan

[8] I Shou Univ, E Da Hosp, Dept Neurol, Kaohsiung, Taiwan

[9] Natl Cheng Kung Univ, Dept Neurol, Coll Med, Tainan, Taiwan

[10] Natl Cheng Kung Univ Hosp, Stroke Ctr, Tainan, Taiwan

[11] Shin Kong Wu Ho Mem Hosp, Dept Neurol, Taipei, Taiwan

[12] Taipei Med Univ, Coll Med, Taipei, Taiwan

[13] Kaohsiung Med Univ Hosp, Dept Neurol, Kaohsiung, Taiwan

[14] Chung Shan Med Univ Hosp, Dept Neurol, Taichung, Taiwan

[15] Chi Mei Med Ctr, Dept Neurol, Tainan, Taiwan

[16] Show Chwan Mem Hosp, Changhua, Taiwan

[17] Cheng Hsin Gen Hosp, Taipei, Taiwan

[18] En Chu Kong Hosp, New Taipei, Taiwan

[19] Far Eastern Mem Hosp, Dept Neurol, Taipei, Taiwan

[20] Chia Yi Christian Hosp, Ditmanson Med Fdn, Chiayi, Taiwan

[21] Taichung Vet Gen Hosp, Taichung, Taiwan

[22] Natl Def Med Ctr, Triserv Gen Hosp, Dept Neurol, Taipei, Taiwan

[23] Cathay Gen Hosp, Taipei, Taiwan

[24] Taipei Tzuchi Hosp, New Taipei, Taiwan

[25] China Med Univ Hosp, Management Off Hlth Data, Taichung, Taiwan

[26] Monash Univ, Melbourne, Vic, Australia

[27] Natl Hlth Res Inst, Inst Populat Sci, Zhunan, Taiwan

来源：

JOURNAL OF STROKE & CEREBROVASCULAR DISEASES | 2017年 / 26卷 / 06期

关键词：

Cholesterol; dialysis; ischemic stroke; mortality; prognosis; CARDIOVASCULAR-DISEASE; HEMODIALYSIS-PATIENTS; KIDNEY-DISEASE; RISK-FACTORS; OUTCOMES; MALNUTRITION; SURVIVAL; EVENTS; TAIWAN; IMPACT;

D O I：

10.1016/j.jstrokecerebrovasdis.2017.02.007

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Background: We investigated the impact of serum cholesterol levels on 30-day mortality after ischemic stroke in dialysis patients. Methods: From the Taiwan Stroke Registry data, we identified 46,770 ischemic stroke cases, including 1101 dialysis patients and 45,669 nondialysis patients from 2006 to 2013. Results: Overall, the 30-day mortality was 1.46-fold greater in the dialysis group than in the nondialysis group (1.75 versus 1.20 per 1000 person-days). The mortality rates were 1.64, .62, 2.82, and 2.23 per 1000 person-days in dialysis patients with serum total cholesterol levels of <120 mg/dL, 120-159 mg/dL, 160-199 mg/dL, and >= 200 mg/dL, respectively. Compared to dialysis patients with serum total cholesterol levels of 120-159 mg/dL, the corresponding adjusted hazard ratios of mortality were 4.20 (95% confidence interval [CI] = 1.01-17.4), 8.06 (95% CI = 2.02-32.2), and 6.89 (95% CI = 1.59-29.8) for those with cholesterol levels of <120 mg/dL, 160199 mg/dL, and = 200 mg/dL, respectively. Conclusions: Dialysis patients with serum total cholesterol levels of >= 160 mg/dL or <120 mg/dL on admission are at an elevated hazard of 30-day mortality after ischemic stroke.

引用

页码：1349 / 1356

页数：8

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