Elevated serum acylated (biologically active) ghrelin and resistin levels associate with pregnancy-induced weight gain and insulin resistance

被引:81
作者
Palik, Eva
Baranyi, Eva
Melczer, Zsolt
Audikovszky, Maria
Szocs, Albert
Winkler, Gabor
Cseh, Karoly
机构
[1] Semmelweis Univ, Dept Med 3, H-1125 Budapest, Hungary
[2] Natl Med Ctr, Diabet Outpatient Unit, Budapest, Hungary
[3] Semmelweis Univ, Dept Obstet & Gynecol 2, H-1085 Budapest, Hungary
[4] St Imre Hosp, Dept Med 4, Budapest, Hungary
[5] St Johns Hosp, Dept Med 2, Budapest, Hungary
[6] Karolyi Hosp, Dept Med 1, Budapest, Hungary
关键词
ghrelin; resistin; pregnancy; gestational diabetes mellitus; insulin resistance; cytokines;
D O I
10.1016/j.diabres.2006.09.005
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Aim: To study fasting biologically active serum ghrelin (RIA) and resistin (ELISA) levels in different trimesters of pregnancy (HP, n = 45 15 in each) and in gestational diabetes mellitus (GDM, n = 30) compared to non-pregnant healthy women (NP, n = 40) in correlation with TNF-alpha, soluble (s)TNF-receptor (R)-1, -2, leptin (ELISA), C-peptide (Cp, RIA) and Cp[blood glucose ratio (bg). Study design: Cross-sectional case control study. Results: Acylated ghrelin levels were significantly increased (p < 0.0001) in the 2nd (377 +/- 38 pg/ml,X +/- S.D.) and decreased in the 3rd trimester (252 36) and in GDM (226 21) compared to NP controls (309 20) and HP women in the 1st trimester (314 +/- 41). Serum resistin levels were higher in the 1st (8.5 +/- 2.6 ng/ml), 2nd (10.2 +/- 2. 1) and 3rd (13.1 +/- 3.6) trimesters of pregnancy and in GDM (15.7 +/- 3.5) than in NP controls (6.5 +/- 2.3). Significant (p < 0.01) negative linear correlations were found among fasting serum ghrelin and body mass index (13MI), the fasting C-peptide (Cp) level, C-peptide/blood glucose (Cp/bg) ratio, TNF-alpha, soluble (s)TNFR-2, leptin and resistin concentrations in both, HP and GDM groups. Significant positive correlations were observed between serum acylated ghrelin and adiponectin, and between BMI and fasting Cp, Cp1bg, TNF-alpha, sTNFR- 1, -2 and leptin levels in both pregnant groups. Conclusion: Increased fasting serum acylated ghrelin concentrations in the 2nd trimester may associate with weight gain during pregnancy. Hyperresistinen-iia may also be associated with the pregnancy-induced insulin resistance. A negative regulatory feedback mechanism between resistin, TNF-alpha and ghrelin may be hypothesized. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:351 / 357
页数:7
相关论文
共 22 条
[1]   An update on the biology and physiology of resistin [J].
Adeghate, E .
CELLULAR AND MOLECULAR LIFE SCIENCES, 2004, 61 (19-20) :2485-2496
[2]   Antagonism of ghrelin receptor reduces food intake and body weight gain in mice [J].
Asakawa, A ;
Inui, A ;
Kaga, T ;
Katsuura, G ;
Fujimiya, M ;
Fujino, MA ;
Kasuga, M .
GUT, 2003, 52 (07) :947-952
[3]   ACRP30/adiponectin: an adipokine regulating glucose and lipid metabolism [J].
Berg, AH ;
Combs, TP ;
Scherer, PE .
TRENDS IN ENDOCRINOLOGY AND METABOLISM, 2002, 13 (02) :84-89
[4]   Ghrelin: The link connecting growth with metabolism and energy homeostasis [J].
Casanueva F.F. ;
Dieguez C. .
Reviews in Endocrine and Metabolic Disorders, 2002, 3 (4) :325-338
[5]   The pathophysiological influence of leptin and the tumor necrosis factor system on maternal insulin resistance:: negative correlation with anthropometric parameters of neonates in gestational diabetes [J].
Cseh, K ;
Baranyi, É ;
Melczer, Z ;
Csákány, GM ;
Speer, G ;
Kovács, M ;
Gerö, G ;
Karádi, I ;
Winkler, G .
GYNECOLOGICAL ENDOCRINOLOGY, 2002, 16 (06) :453-460
[6]   Plasma adiponectin and pregnancy -: Induced insulin resistance [J].
Cseh, KR ;
Baranyi, E ;
Melczer, Z ;
Kaszás, E ;
Palik, E ;
Winkler, G .
DIABETES CARE, 2004, 27 (01) :274-275
[7]  
De Ambrogi Marco, 2003, Med Sci Monit, V9, pRA217
[8]   Ghrelin inhibits leptin- and activation-induced proinflammatory cytokine expression by human monocytes and T cells [J].
Dixit, VD ;
Schaffer, EM ;
Pyle, RS ;
Collins, GD ;
Sakthivel, SK ;
Palaniappan, R ;
Lillard, JW ;
Taub, DD .
JOURNAL OF CLINICAL INVESTIGATION, 2004, 114 (01) :57-66
[9]   Ghrelin and its relationship to growth hormones during normal pregnancy [J].
Fuglsang, J ;
Skjærbæk, C ;
Espelund, U ;
Frystyk, J ;
Fisker, S ;
Flyvbjerg, A ;
Ovesen, P .
CLINICAL ENDOCRINOLOGY, 2005, 62 (05) :554-559
[10]   The expression of the growth hormone secretagogue receptor ligand ghrelin in normal and abnormal human pituitary and other neuroendocrine tumors [J].
Korbonits, M ;
Bustin, SA ;
Kojima, M ;
Jordan, S ;
Adams, EF ;
Lowe, DG ;
Kangawa, K ;
Grossman, AB .
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM, 2001, 86 (02) :881-887