Current concepts in the prevention of pathogen transmission via blood/plasma-derived products for bleeding disorders

被引：30

作者：

Di Minno, Giovanni ^{[1
]}

Perno, Carlo Federico ^{[2
]}

Tiede, Andreas ^{[3
]}

Navarro, David ^{[4
]}

Canaro, Mariana ^{[5
]}

Gueertler, Lutz ^{[6
]}

Ironside, James W. ^{[7
]}

机构：

[1] Univ Naples Federico II, Reg Reference Ctr Coagulat Disorders, Dipartimento Med Clin & Chirurg, Via S Pansini 5, I-80131 Naples, Italy

[2] Univ Roma Tor Vergata, Dept Expt Med & Surg, Via Montpellier 1, I-00133 Rome, Italy

[3] Hannover Med Sch, Dept Hematol Hemostasis Oncol & Stem Cell Transpl, Carl Neuberg Str 1, D-30625 Hannover, Germany

[4] Univ Valencia, Sch Med, Hosp Clin Univ, Dept Microbiol,Microbiol Serv, Av Blasco Ibanez 17, Valencia 46010, Spain

[5] Son Espases Univ Hosp, Dept Hemostasis & Thrombosis, Carretera Valdemossa 79, Palma De Mallorca 07120, Spain

[6] Univ Munich, Max von Pettenkofer Inst Hyg & Med Microbiol, Pettenkofer Str 9A, D-80336 Munich, Germany

[7] Univ Edinburgh, Western Gen Hosp, Natl Creutzfeldt Jakob Dis Res & Surveillance Uni, Sch Clin Sci, Edinburgh EH4 2XU, Midlothian, Scotland

来源：

BLOOD REVIEWS | 2016年 / 30卷 / 01期

关键词：

Pathogen; Transfusion; Blood safety; Clotting; Haemophilia; HEPATITIS-E VIRUS; HUMAN-IMMUNODEFICIENCY-VIRUS; WEST NILE VIRUS; HUMAN PARVOVIRUS 4; CREUTZFELDT-JAKOB-DISEASE; REAL-TIME PCR; SARCOMA-ASSOCIATED HERPESVIRUS; BLOOD-DONORS; DIAGNOSTIC-ACCURACY; C-VIRUS;

D O I：

10.1016/j.blre.2015.07.004

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The pathogen safety of blood/plasma-derived products has historically been a subject of significant concern to the medical community, Measures such as donor selection and blood screening have contributed to increase the safety of these products, but pathogen transmission does still occur. Reasons for this include lack of sensitivity/specificity of current screening methods, lack of reliable screening tests for some pathogens (e.g. prions) and the fact that many potentially harmful infectious agents are not routinely screened for. Methods for the purification/inactivation of blood/plasma-derived products have been developed in order to further reduce the residual risk, but low concentrations of pathogens do not necessarily imply a low level of risk for the patient and so the overall challenge of minimising risk remains. This review aims to discuss the variable level of pathogenic risk and describes the current screening methods used to prevent/detect the presence of pathogens in blood/plasma-derived products. (C) 2015 The Authors. Published by Elsevier Ltd.

引用

页码：35 / 48

页数：14

共 185 条

[1] Evaluation of PCR procedures for detecting and quantifying Leishmania donovani DNA in large numbers of dried human blood samples from a visceral leishmaniasis focus in Northern Ethiopia [J].