RNA Nanotechnology-Mediated Cancer Immunotherapy

被引：119

作者：

Lin, Yao-Xin ^{[1
,2
]}

Wang, Yi ^{[1
,2
,3
,5
]}

Blake, Sara ^{[1
,2
,6
]}

Yu, Mian ^{[4
]}

Mei, Lin ^{[4
]}

Wang, Hao ^{[3
,5
]}

Shi, Jinjun ^{[1
,2
]}

机构：

[1] Harvard Med Sch, Brigham & Womens Hosp, Ctr Nanomed, Boston, MA 02115 USA

[2] Harvard Med Sch, Brigham & Womens Hosp, Dept Anesthesiol, Boston, MA 02115 USA

[3] Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China

[4] Sun Yat Sen Univ, Sch Pharmaceut Sci Shenzhen, Guangzhou 510006, Guangdong, Peoples R China

[5] Univ Chinese Acad Sci, Ctr Mat Sci & Optoelect Engn, Beijing 100049, Peoples R China

[6] Tufts Univ, Medford, MA 02155 USA

来源：

THERANOSTICS | 2020年 / 10卷 / 01期

基金：

中国博士后科学基金;

关键词：

RNA; nanoparticle; immunotherapy; cancer; RNAi; CRISPR; SMALL-INTERFERING RNA; SENSITIVE POLYMERIC NANOPARTICLES; MESOPOROUS SILICA NANOPARTICLES; TUMOR-ASSOCIATED MACROPHAGES; LIPID-BASED NANOPARTICLES; DRUG-DELIVERY SYSTEMS; REGULATORY T-CELLS; MESSENGER-RNA; DENDRITIC CELLS; SIRNA DELIVERY;

D O I：

10.7150/thno.35568

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

RNA molecules (e.g., siRNA, microRNA, and mRNA) have shown tremendous potential for immunomodulation and cancer immunotherapy. They can activate both innate and adaptive immune system responses by silencing or upregulating immune-relevant genes. In addition, mRNA-based vaccines have recently been actively pursued and tested in cancer patients, as a form of treatment. Meanwhile, various nanomaterials have been developed to enhance RNA delivery to the tumor and immune cells. In this review article, we summarize recent advances in the development of RNA-based therapeutics and their applications in cancer immunotherapy. We also highlight the variety of nanoparticle platforms that have been used for RNA delivery to elicit anti-tumor immune responses. Finally, we provide our perspectives of potential challenges and opportunities of RNA-based nanotherapeutics in clinical translation towards cancer immunotherapy.

引用

页码：281 / 299

页数：19

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