RNA Nanotechnology-Mediated Cancer Immunotherapy

被引：113
作者：
Lin, Yao-Xin [1 ,2 ]
Wang, Yi [1 ,2 ,3 ,5 ]
Blake, Sara [1 ,2 ,6 ]
Yu, Mian [4 ]
Mei, Lin [4 ]
Wang, Hao [3 ,5 ]
Shi, Jinjun [1 ,2 ]
机构：
[1] Harvard Med Sch, Brigham & Womens Hosp, Ctr Nanomed, Boston, MA 02115 USA
[2] Harvard Med Sch, Brigham & Womens Hosp, Dept Anesthesiol, Boston, MA 02115 USA
[3] Natl Ctr Nanosci & Technol, CAS Key Lab Biomed Effects Nanomat & Nanosafety, CAS Ctr Excellence Nanosci, Beijing 100190, Peoples R China
[4] Sun Yat Sen Univ, Sch Pharmaceut Sci Shenzhen, Guangzhou 510006, Guangdong, Peoples R China
[5] Univ Chinese Acad Sci, Ctr Mat Sci & Optoelect Engn, Beijing 100049, Peoples R China
[6] Tufts Univ, Medford, MA 02155 USA
来源：
THERANOSTICS | 2020年 / 10卷 / 01期
基金：
中国博士后科学基金;
关键词：
RNA; nanoparticle; immunotherapy; cancer; RNAi; CRISPR; SMALL-INTERFERING RNA; SENSITIVE POLYMERIC NANOPARTICLES; MESOPOROUS SILICA NANOPARTICLES; TUMOR-ASSOCIATED MACROPHAGES; LIPID-BASED NANOPARTICLES; DRUG-DELIVERY SYSTEMS; REGULATORY T-CELLS; MESSENGER-RNA; DENDRITIC CELLS; SIRNA DELIVERY;
D O I：
10.7150/thno.35568
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
RNA molecules (e.g., siRNA, microRNA, and mRNA) have shown tremendous potential for immunomodulation and cancer immunotherapy. They can activate both innate and adaptive immune system responses by silencing or upregulating immune-relevant genes. In addition, mRNA-based vaccines have recently been actively pursued and tested in cancer patients, as a form of treatment. Meanwhile, various nanomaterials have been developed to enhance RNA delivery to the tumor and immune cells. In this review article, we summarize recent advances in the development of RNA-based therapeutics and their applications in cancer immunotherapy. We also highlight the variety of nanoparticle platforms that have been used for RNA delivery to elicit anti-tumor immune responses. Finally, we provide our perspectives of potential challenges and opportunities of RNA-based nanotherapeutics in clinical translation towards cancer immunotherapy.
引用
收藏
页码：281 / 299
页数：19
相关论文
共 50 条
  • [31] Cancer Vaccines and Beyond: The Transformative Role of Nanotechnology in Immunotherapy
    Delgado-Almenta, Violeta
    Blaya-Canovas, Jose L.
    Calahorra, Jesus
    Lopez-Tejada, Araceli
    Grinan-Lison, Carmen
    Granados-Principal, Sergio
    [J]. PHARMACEUTICS, 2025, 17 (02)
  • [32] Nanotechnology-based multifunctional vaccines for cancer immunotherapy
    Xie, Xiaoxue
    Song, Ting
    Feng, Yi
    Zhang, Hanxi
    Yang, Geng
    Wu, Chunhui
    You, Fengming
    Liu, Yiyao
    Yang, Hong
    [J]. CHEMICAL ENGINEERING JOURNAL, 2022, 437
  • [33] Advancing Cancer Treatment Through Nanotechnology Driven Immunotherapy for Pancreatic Cancer
    Sreejith, T.
    Kamalasanan, Kaladhar
    Sneha, S.
    Keechilat, Pavithran
    Harb, Hani
    [J]. ACS APPLIED NANO MATERIALS, 2023, 6 (20) : 18670 - 18697
  • [34] Nanotechnology for the Development of Nanovaccines in Cancer Immunotherapy
    Grimaudo, Maria Aurora
    [J]. BIO-NANOMEDICINE FOR CANCER THERAPY, 2021, 1295 : 303 - 315
  • [35] RNA pulsed dendritic cells: An approach for cancer immunotherapy
    Garg, Neeraj Kumar
    Dwivedi, Priya
    Prabha, Punit
    Tyagi, Rajeev K.
    [J]. VACCINE, 2013, 31 (08) : 1141 - 1156
  • [36] Nanotechnology Approaches to Improving Cancer Immunotherapy
    Hagan, C. Tilden
    Medik, Yusra B.
    Wang, Andrew Z.
    [J]. CANCER NANOTECHNOLOGY-BOOK, 2018, 139 : 35 - 56
  • [37] Nanoparticle mediated cancer immunotherapy
    Gupta, Jyoti
    Safdari, Haaris Ahsan
    Hoque, Mehboob
    [J]. SEMINARS IN CANCER BIOLOGY, 2021, 69 : 307 - 324
  • [38] Recent advancements in immunotherapy of melanoma using nanotechnology-based strategies
    Bahreyni, Amirhossein
    Mohamud, Yasir
    Luo, Honglin
    [J]. BIOMEDICINE & PHARMACOTHERAPY, 2023, 159
  • [39] Biomimetic nanotechnology for cancer immunotherapy: State of the art and future perspective
    Lotfabadi, Alireza Sarkar
    Abadi, Banafshe
    Rezaei, Nima
    [J]. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 2024, 654
  • [40] Phage Display-Based Nanotechnology Applications in Cancer Immunotherapy
    Goracci, Martina
    Pignochino, Ymera
    Marchio, Serena
    [J]. MOLECULES, 2020, 25 (04):
12345