Antioxidant and Protective Effects of Major Flavonoids from Teucrium polium on β-Cell Destruction in a Model of Streptozotocin-Induced Diabetes

被引：54

作者：

Esmaeili, Mohammad Ali ^{[1
]}

Zohari, Fereshteh ^{[1
]}

Sadeghi, Heibatollah ^{[2
]}

机构：

[1] Shahid Beheshti Univ GC, Dept Biol, Med Plants & Drug Res Inst, Tehran, Iran

[2] Yasuj Univ Med Sci, Dept Biochem, Fac Med, Herbal Med Res Ctr, Yasuj, Iran

来源：

PLANTA MEDICA | 2009年 / 75卷 / 13期

关键词：

flavonoids; hypoglycemic; insulin; Lamiaceae; Teucrium polium; RAT PANCREATIC-ISLETS; IN-VITRO; RUTIN;

D O I：

10.1055/s-0029-1185704

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The hypoglycemic effect of Teucrium polium has been accounted for by its constituents that increase insulin release. The present study aimed to investigate whether the major flavonoid compounds (rutin and apigenin) from the methanol extract of Teucrium polium would stimulate insulin secretion and, if so, to further elucidate the mechanism behind this effect. Isolated rat pancreatic islets were batch incubated to study the effect of rutin and apigenin on insulin secretion at various glucose concentrations. Treated islets in the presence of streptozotocin (STZ) and flavonoid Compounds significantly increased insulin release by almost 56% compared with STZ-treated islets. Our data indicated that the flavonoids in T polium extract appeared to be helpful in protecting pancreatic islets against exposure to STZ in vitro due to their antioxidant activity.

引用

页码：1418 / 1420

页数：3

共 16 条

[1] Antinociceptive effects of Teucrium polium L. total extract and essential oil in mouse writhing test [J].

Abdollahi, M ;

Karimpour, H ;

Monsef-Esfehani, HR .

PHARMACOLOGICAL RESEARCH, 2003, 48 (01) :31-35

[2] ANTIOXIDANT DETERMINATIONS BY THE USE OF A STABLE FREE RADICAL [J].

BLOIS, MS .

NATURE, 1958, 181 (4617) :1199-1200

[3] Hypoglycaemic effect of Teucrium polium:: studies with rat pancreatic islets [J].

Esmaeili, MA ;

Yazdanparast, R .

JOURNAL OF ETHNOPHARMACOLOGY, 2004, 95 (01) :27-30

[4] Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships [J].

Heim, KE ;

Tagliaferro, AR ;

Bobilya, DJ .

JOURNAL OF NUTRITIONAL BIOCHEMISTRY, 2002, 13 (10) :572-584

[5] Rutin improves the antioxidant status in streptozotocin-induced diabetic rat tissues [J].

Kamalakkannan, N. ;

Prince, P. Stanely Mainzen .

MOLECULAR AND CELLULAR BIOCHEMISTRY, 2006, 293 (1-2) :211-219

[6] Protective effects of epicatechin against the toxic effects of streptozotocin on rat pancreatic islets: In vivo and in vitro [J].

Kim, MJ ;

Ryu, GR ;

Chung, JS ;

Sim, SS ;

Min, DS ;

Rhie, DJ ;

Yoon, SH ;

Hahn, SJ ;

Kim, MS ;

Jo, YH .

PANCREAS, 2003, 26 (03) :292-299

[7] Distributional patterns of phospholipase C isozymes in rat pancreas [J].

Kim, MJ ;

Lee, KH ;

Min, DS ;

Yoon, SH ;

Hahn, SJ ;

Kim, MS ;

Jo, YH .

PANCREAS, 2001, 22 (01) :47-52

[8] Silymarin protects pancreatic β-cells against cytokine-mediated toxicity:: Implication of c-Jun NH2-terminal kinase and Janus kinase/signal transducer and activator of transcription pathways [J].

Matsuda, T ;

Ferreri, K ;

Todorov, I ;

Kuroda, Y ;

Smith, CV ;

Kandeel, F ;

Mullen, Y .

ENDOCRINOLOGY, 2005, 146 (01) :175-185

[9] A FLUOROMETRIC ASSAY FOR THE MEASUREMENT OF NITRITE IN BIOLOGICAL SAMPLES [J].

MISKO, TP ;

SCHILLING, RJ ;

SALVEMINI, D ;

MOORE, WM ;

CURRIE, MG .

ANALYTICAL BIOCHEMISTRY, 1993, 214 (01) :11-16

[10]

PRINCEVIJEYASIN.J, 2004, PHYTOMEDICINE, V11, P309

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